Boc-Cys(1)-Arg(Tos)-Gly-Asp(OcHex)-Phe-Pro-Ala-Ser(Bn)-Ser(Bn)-Cys(1)-OMe | 166184-22-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Cys(1)-Arg(Tos)-Gly-Asp(OcHex)-Phe-Pro-Ala-Ser(Bn)-Ser(Bn)-Cys(1)-OMe
• 英文别名: methyl (3S,6S,12S,15R,20R,23S,26S,29S,32S)-12-[3-[[amino-[(4-methylphenyl)sulfonylamino]methylidene]amino]propyl]-3-benzyl-6-(2-cyclohexyloxy-2-oxoethyl)-29-methyl-15-[(2-methylpropan-2-yl)oxycarbonylamino]-2,5,8,11,14,22,25,28,31-nonaoxo-23,26-bis(phenylmethoxymethyl)-17,18-dithia-1,4,7,10,13,21,24,27,30-nonazabicyclo[30.3.0]pentatriacontane-20-carboxylate
• CAS: 166184-22-1
• 化学式: C₇₄H₉₉N₁₃O₁₉S₃
• 分子量: 1570.87
• InChiKey: DGEPVNOGRJUUEU-FJLLAKPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  109
• 可旋转键数：
  26
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  506
• 氢给体数：
  11
• 氢受体数：
  22

反应信息

• 作为反应物：
  描述：

  Boc-Cys(1)-Arg(Tos)-Gly-Asp(OcHex)-Phe-Pro-Ala-Ser(Bn)-Ser(Bn)-Cys(1)-OMe 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Synthesis of RGDFPASS-containing Cystine Peptides and Isolation of RGD-recognizing Receptor in Sand Dollar Embryo by the Peptide-Affinity Chromatography

  摘要：

  RGDFPASS-containing cystine decapeptides were synthesized by the solution method. These peptides strongly inhibited platelet aggregation. N-Acetyl and C-methoxy peptide ([Phe5]-FR-1-AM) having amphiphilic structure exhibited especially high activity as a platelet aggregation inhibitor. A 240 kDa RGD-recognizing receptor was obtained from a sand dollar embryo by RGDFPASS-containing peptide-affinity chromatography.

  DOI：

  10.1246/cl.1995.483
• 作为产物：
  描述：

  Boc-Cys(Acm)-Arg(Tos)-Gly-Asp(OcHex)-Phe-Pro-Ala-Ser(Bn)-Ser(Bn)-Cys(Acm)-OMe 在 碘 作用下， 以 甲醇 为溶剂， 反应 0.17h， 以55%的产率得到Boc-Cys(1)-Arg(Tos)-Gly-Asp(OcHex)-Phe-Pro-Ala-Ser(Bn)-Ser(Bn)-Cys(1)-OMe
  参考文献：
  名称：

  Synthesis of RGDFPASS-containing Cystine Peptides and Isolation of RGD-recognizing Receptor in Sand Dollar Embryo by the Peptide-Affinity Chromatography

  摘要：

  RGDFPASS-containing cystine decapeptides were synthesized by the solution method. These peptides strongly inhibited platelet aggregation. N-Acetyl and C-methoxy peptide ([Phe5]-FR-1-AM) having amphiphilic structure exhibited especially high activity as a platelet aggregation inhibitor. A 240 kDa RGD-recognizing receptor was obtained from a sand dollar embryo by RGDFPASS-containing peptide-affinity chromatography.

  DOI：

  10.1246/cl.1995.483