ethyl 5-({2-[4-(methoxycarbonyl)phenyl]ethyl}-{2-[2-({4-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]-benzyl}oxy)phenyl]ethyl}amino)-5,6,7,8-tetra-hydroquinoline-2-carboxylate | 1542133-40-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: ethyl 5-({2-[4-(methoxycarbonyl)phenyl]ethyl}-{2-[2-({4-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]-benzyl}oxy)phenyl]ethyl}amino)-5,6,7,8-tetra-hydroquinoline-2-carboxylate
• 英文别名: Ethyl 5-[2-(4-methoxycarbonylphenyl)ethyl-[2-[2-[[4-[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]phenyl]methoxy]phenyl]ethyl]amino]-5,6,7,8-tetrahydroquinoline-2-carboxylate
• CAS: 1542133-40-3
• 化学式: C₄₅H₄₂F₃N₃O₆
• 分子量: 777.84
• InChiKey: ZDPWWXNPCRNSPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  57
• 可旋转键数：
  16
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• Novel 5-aminotetrahydroquinoline-2-carboxylic acids and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20140031391A1

  公开（公告）日：2014-01-30

  The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

  本申请涉及新颖的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，以及它们的制备方法，它们用于治疗和/或预防疾病，以及它们用于生产用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病。
• NOVEL 5-AMINOTETRAHYDROQUINOLINE-2-CARBOXYLIC ACIDS AND THEIR USE
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20150148376A1

  公开（公告）日：2015-05-28

  The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

  本申请涉及新型5-氨基-5,6,7,8-四氢喹啉-2-羧酸的制备方法、其用于治疗和/或预防疾病的用途以及用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管和心肺疾病的用途。
• 5-aminotetrahydroquinoline-2-carboxylic acids and their use
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US10053428B2

  公开（公告）日：2018-08-21

  The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.

  本申请涉及新型 5-氨基-5,6,7,8-四氢喹啉-2-羧酸、其制备工艺、其治疗和/或预防疾病的用途，以及其用于生产治疗和/或预防疾病，特别是治疗和/或预防心血管和心肺疾病的药物。
• NEUE 5-AMINOTETRAHYDROCHINOLIN-2-CARBONSÄUREN UND IHRE VERWENDUNG
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2875003B1

  公开（公告）日：2016-11-16
• US8981104B2
  申请人：——

  公开号：US8981104B2

  公开（公告）日：2015-03-17