Propyl-tetradecyl-malonsaeurediethylester | 56256-88-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Propyl-tetradecyl-malonsaeurediethylester
• 英文别名: Propyl-myristyl-malonsaeure-diethylester；propyl-tetradecyl-malonic acid diethyl ester；Propyl-tetradecyl-malonsaeure-diaethylester；diethyl propyltetradecylmalonate；Diethyl 2-propyl-2-tetradecylpropanedioate
• CAS: 56256-88-3
• 化学式: C₂₄H₄₆O₄
• 分子量: 398.627
• InChiKey: OCSXBKKWNWCTDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  28
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Propyl-tetradecyl-malonsaeurediethylester 生成 2-Propyl-hexadecansaeure
  参考文献：
  名称：

  Greer; Adams, Journal of the American Chemical Society, 1930, vol. 52, p. 2541

  摘要：

  DOI：

文献信息

• Use of branched chain fatty acids and derivatives thereof for inhibition of P-glycoprotein
  申请人：D-Pharm Limited

  公开号：US06605638B1

  公开（公告）日：2003-08-12

  The invention relates to the use of branched chain fatty acids (BFAs) and their derivatives for inhibition of the activity of P-glycoprotein (P-gp). In particular, the invention relates to the use of BFAs and their derivatives in the treatment of multi-drug resistant (MDR) tumors associated with increased activity of P-glycoprotein. The invention also relates to the use of the above-mentioned molecules for administration of biologically active molecules and diagnostic agents into cells associated with increased activity of P-gp, and for increasing accumulation of biologically active molecules and diagnostic agents in organs protected by biological barriers.

  本发明涉及使用支链脂肪酸（BFA）及其衍生物来抑制P-糖蛋白（P-gp）的活性。特别是，本发明涉及使用BFA及其衍生物来治疗与P-gp活性增加相关的多药耐药（MDR）肿瘤。本发明还涉及使用上述分子将生物活性分子和诊断剂输送到与P-gp活性增加相关的细胞中，并增加生物障碍保护的器官中生物活性分子和诊断剂的积累。
• Compositions and methods for reversibly increasing permeability of biomembranes
  申请人：D-Pharm Ltd.

  公开号：US06319952B1

  公开（公告）日：2001-11-20

  The present invention provides a family of branched fatty acids and their derivatives, which improve and enable the penetration and absorption of active ingredients through biomembranes, such as blood brain barrier. The invention further provides pharmaceutical compositions comprising these branched fatty acids and methods of using these compositions to permeabilize biological membranes thereby improving the administration of bioactive or therapeutic substances to cells or organs. According to a more preferred embodiment of this invention the methods are particularly useful to treat certain kinds of CNS lesions and diseases including tumors, infections, abscesses and degenerative and behavioral disorders.

  本发明提供了一系列支链脂肪酸及其衍生物，可以促进和使活性成分穿过生物膜，如血脑屏障的吸收。该发明进一步提供了包含这些支链脂肪酸的药物组合物，以及使用这些组合物透过生物膜，从而改善向细胞或器官中给药的生物活性或治疗物质的方法。根据本发明更优选的实施方式，这些方法特别适用于治疗某些中枢神经系统损伤和疾病，包括肿瘤、感染、脓肿和退行性及行为障碍。
• STAELLBERG G., CHEM. SCRIPTA <CSRP-B9>, 1975, 7, NO 1, 31-41
  作者：STAELLBERG G.

  DOI：——

  日期：——
• COMPOSITIONS AND METHODS FOR REVERSIBLY INCREASING PERMEABILITY OF BIOMEMBRANES
  申请人：D-PHARM, LTD.

  公开号：EP1007506A2

  公开（公告）日：2000-06-14
• US6319952B1
  申请人：——

  公开号：US6319952B1

  公开（公告）日：2001-11-20