Methyl 4-[methyl-[3-[2-methyl-5-phenyl-3-[[3-(trifluoromethyl)phenyl]carbamoyl]pyrrol-1-yl]propyl]amino]butanoate | 1403945-52-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Methyl 4-[methyl-[3-[2-methyl-5-phenyl-3-[[3-(trifluoromethyl)phenyl]carbamoyl]pyrrol-1-yl]propyl]amino]butanoate
• CAS: 1403945-52-7
• 化学式: C₂₈H₃₂F₃N₃O₃
• 分子量: 515.576
• InChiKey: IDXVLEPITTVCFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• AROMATIC HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY
  申请人：Yukimasa Akira

  公开号：US20140024647A1

  公开（公告）日：2014-01-23

  A compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof is provided. The present invention is related to a compound represented by the formula (I), wherein R 1a is substituted or unsubstituted alkyl or the like; R 1b is hydrogen or substituted or unsubstituted alkyl; R 1c is hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted nonaromatic heterocyclic group or the like; -L- is —C(=0)—NR 2− or the like; X is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or the like, or a pharmaceutically acceptable salt thereof.
• US9340500B2
  申请人：——

  公开号：US9340500B2

  公开（公告）日：2016-05-17