4-(1-{[4-(morpholin-4-yl)phenyl]amino}-8-oxo-7,8-dihydro-2,7-naphthyridin-3-yl)-3,4-dihydro-2H-1,4-benzothiazine-1,1-dione | 1175550-58-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(1-{[4-(morpholin-4-yl)phenyl]amino}-8-oxo-7,8-dihydro-2,7-naphthyridin-3-yl)-3,4-dihydro-2H-1,4-benzothiazine-1,1-dione
• 英文别名: 6-(1,1-dioxo-2,3-dihydro-1lambda6,4-benzothiazin-4-yl)-8-(4-morpholin-4-ylanilino)-2H-2,7-naphthyridin-1-one；6-(1,1-dioxo-2,3-dihydro-1λ6,4-benzothiazin-4-yl)-8-(4-morpholin-4-ylanilino)-2H-2,7-naphthyridin-1-one
• CAS: 1175550-58-9
• 化学式: C₂₆H₂₅N₅O₄S
• 分子量: 503.582
• InChiKey: KHHAHZGAPWWCSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS
  申请人：Okram Barun

  公开号：US20110003798A1

  公开（公告）日：2011-01-06

  The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof.

  本发明提供了一类新型的2,7-萘啶衍生物；包含这些化合物的药物组合物以及使用这些化合物治疗或预防与异常或调节不良的激酶活性相关的疾病或疾病的方法，特别是Syk，ZAP70，KDR，FMS，FLT*，c-Kit，RET，TrkA，TrkB，TrkC-GR-1R，Alk，c-FMS或其组合。
• US8546370B2
  申请人：——

  公开号：US8546370B2

  公开（公告）日：2013-10-01
• [EN] COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS ET COMPOSITIONS COMME INHIBITEURS DE KINASES
  申请人：IRM LLC

  公开号：WO2009097287A1

  公开（公告）日：2009-08-06

  The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity,particulary Syk,ZAP70,KDR,FMS,FLT*,c-Kit,RET,TrkA,TrkB,TrkC-GR-1R,Alk,c- FMS.or combinations thereof.