2-[3-[2-(4-methylpiperazin-1-yl)ethoxy]anilino]-7-pentan-3-yl-5H-pyrrolo[2,3-d]pyrimidin-6-one | 959796-11-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[3-[2-(4-methylpiperazin-1-yl)ethoxy]anilino]-7-pentan-3-yl-5H-pyrrolo[2,3-d]pyrimidin-6-one
• CAS: 959796-11-3
• 化学式: C₂₄H₃₄N₆O₂
• 分子量: 438.573
• InChiKey: LFMIMKUNGTWAFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  73.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Pyrrolopyrimidine Compounds and Their Uses
  申请人：Brain Christopher Thomas

  公开号：US20090318441A1

  公开（公告）日：2009-12-24

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrrolopyrimidine compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.

  本申请描述了对治疗、预防及/或改善疾病有用的有机化合物，特别是描述了抑制蛋白激酶的吡咯并嘧啶化合物及其衍生物。这些有机化合物在治疗增殖性疾病中是有用的。
• Combination Comprising a Cyclin Dependent Kinase 4 or Cyclin Dependent Kinase (CDK4/6) Inhibitor for Treating Cancer
  申请人：Borland Maria

  公开号：US20160008367A1

  公开（公告）日：2016-01-14

  A combination of a CDK4/6 inhibitor and an mTOR inhibitor for the treatment of cancer.

  一种CDK4/6抑制剂和mTOR抑制剂的组合，用于癌症治疗。
• [EN] COMBINATION COMPRISING A CYCLIN DEPENDENT KINASE 4 OR CYCLIN DEPENDENT KINASE (CDK4/6) INHIBITOR AND AN MTOR INHIBITOR FOR TREATING CANCER<br/>[FR] COMBINAISON COMPRENANT UN INHIBITEUR DE KINASES 4 CYCLINES-DÉPENDANTES OU DE KINASES 6 CYCLINES-DÉPENDANTES (CDK4/6) ET UN INHIBITEUR DE MTOR POUR LE TRAITEMENT DU CANCER
  申请人：NOVARTIS AG

  公开号：WO2011130232A1

  公开（公告）日：2011-10-20

  A combination of a CDK4/6 inhibitor and an mTOR inhibitor for the treatment of cancer.

  一种CDK4/6抑制剂和mTOR抑制剂的组合，用于治疗癌症。
• COMBINATION COMPRISING A CYCLIN DEPENDENT KINASE 4 OR CYCLIN DEPENDENT KINASE (CDK4/6) INHIBITOR FOR TREATING CANCER
  申请人：Borland Maria

  公开号：US20130035336A1

  公开（公告）日：2013-02-07

  A combination of a CDK4/8 inhibitor and an mTOR inhibitor for the treatment of cancer.

  一种CDK4/8抑制剂和mTOR抑制剂的组合，用于癌症治疗。
• PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES
  申请人：BRAIN Christopher Thomas

  公开号：US20120207763A1

  公开（公告）日：2012-08-16

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases, particularly pyrrolopyrimidine compounds and derivatives are described which inhibit protein kinases. The organic compounds are useful in treating proliferative disease.

  本申请描述了有机化合物，这些化合物对于治疗、预防和/或改善疾病非常有用，特别是描述了能够抑制蛋白激酶的吡咯吡嗪化合物和衍生物。这些有机化合物在治疗增殖性疾病方面非常有用。