5-(3,4,5-trimethoxyphenyl)-2,4-pentadienic acid | 111954-02-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(3,4,5-trimethoxyphenyl)-2,4-pentadienic acid
• 英文别名: 5-(3,4,5-Trimethoxyphenyl)penta-2,4-dienoic acid
• CAS: 111954-02-0
• 化学式: C₁₄H₁₆O₅
• 分子量: 264.278
• InChiKey: WQIHERMZQSQZPC-UHFFFAOYSA-N

物化性质

• 熔点：
  162.5-163.0 °C(Solv: benzene (71-43-2))
• 沸点：
  456.5±45.0 °C(Predicted)
• 密度：
  1.181±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Cyclic amide compound
  申请人：KOWA CO., LTD.

  公开号：US20030096828A1

  公开（公告）日：2003-05-22

  The invention relates to compounds represented by the following general formula (1): 1 wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Yi s a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.

  该发明涉及由以下一般式（1）表示的化合物： 1 其中A是可能被取代的芳香化合物，B是氮原子或CH等，X是可能被取代的较低烷基基团，Y是单键等；Z是可能被取代的苯的二价残基，m和n分别是1到4的整数，以及包含这种化合物的药物。这些化合物对IgE抗体的产生具有出色的抑制作用，因此可用作抗过敏药物等。
• Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
  申请人：TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION

  公开号：EP0157420A2

  公开（公告）日：1985-10-09

  According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient. The above-mentioned compounds of the invention have been demonstrated to possess 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC4 and LTD4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.

  根据本发明，提供了新型酰胺衍生物和以酰胺衍生物为有效成分的 5-脂氧合酶抑制剂。 上述本发明化合物已被证实具有 5-脂氧合酶抑制活性。 这些化合物可以通过抑制 5-脂氧合酶的活性来抑制白三烯（如 LTC4 和 LTD4）的产生，而白三烯是过敏诱因。 因此，酰胺衍生物可用作 5-脂氧合酶抑制剂，对过敏性哮喘、过敏性鼻炎等有效。
• Piperazine Derivatives
  申请人：TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION

  公开号：EP0175331A1

  公开（公告）日：1986-03-26

  There are disclosed novel piperazine derivatives and vasodilators containing the same. The compounds are useful for controlling or preventing vascular disorders such as cerebral embolism, myocardial infarction and limb arterial obstruction. As typical compounds are mentioned 1-[5-(3,4,5-trimethoxyphenyl) -2,4-pentadienoyl] -4-(pyrrolidinocarbonylmethyl) -piperazine, 1-[5-(3,4,5-trimethoxyphenyl) - 2,4-pentadienoyl] -4- (N-isopropylaminocarbonylmethyl) - piperazine, 1-[5-(3,4,5-trimethoxyphenyl) -2,4-pentadienoyl] -4- (N,N-dimethylaminocarbonylmethyl) -piperazine and 1-[5-(3,4,5-trimethoxyphenyl) -2,4-pentadienoyl] -4- (methyl- aminocarbonylmethyl) -piperazine.

  本文公开了新型哌嗪衍生物和含有这些衍生物的血管扩张剂。这些化合物可用于控制或预防血管疾病，如脑栓塞、心肌梗塞和肢体动脉阻塞。典型的化合物包括 1-[5-（3,4,5-三甲氧基苯基）-2,4-戊二烯酰基] -4-（吡咯烷羰基甲基）-哌嗪、1-[5-（3,4,5-三甲氧基苯基）-2,4-戊二烯酰基] -4-（N-异丙基氨基羰基甲基）-哌嗪、1-[5-(3,4,5-三甲氧基苯基) -2,4-戊二烯酰] -4-(N,N-二甲基氨基羰基甲基) -哌嗪和 1-[5-(3,4,5-三甲氧基苯基) -2,4-戊二烯酰] -4-(甲基氨基羰基甲基) -哌嗪。
• Nitrate derivatives and their use as vasodilators
  申请人：TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION

  公开号：EP0236227A1

  公开（公告）日：1987-09-09

  Novel nitrate derivatives of the formula are disclosed. As examples of said nitrate derivative are described N-(β-hydroxyethyl)-5-(3,4,5-trimethoxy­phenyl)-2,4-pentadienoic acid amide nitrate, N-(β-hydroxy­ethyl)-3,4,5-trimethoxycinnamic acid amide nitrate and the like. These nitrate derivatives are useful as vaso­dilators.

  公开了式 的新型硝酸酯衍生物。作为所述硝酸盐衍生物的实例，描述了 N-(β-羟乙基)-5-(3,4,5-三甲氧基苯基)-2,4-戊二烯酸酰胺硝酸盐、N-(β-羟乙基)-3,4,5-三甲氧基肉桂酸酰胺硝酸盐等。这些硝酸酯衍生物可用作血管扩张剂。
• CYCLIC AMIDE COMPOUNDS
  申请人：Kowa Co., Ltd.

  公开号：EP1057815A1

  公开（公告）日：2000-12-06

  The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.

  本发明涉及由以下通式（1）表示的化合物： 其中 A 是可被取代的芳香族化合物或类似物，B 是氮原子或 CH，X 是可被取代的低级亚烷基或类似物，Y 是单键或类似物；Z 是可被取代的苯的二价残基或类似物，m 和 n 独立地为 1 至 4 的整数，以及包含这种化合物的药物。这些化合物对 IgE 抗体的产生有很好的抑制作用，因此可用作抗过敏剂等。