(2R,3R,4R,5R)-N-(2-((3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)propyl)amino)ethyl)-2,3,5,6-tetrahydroxy-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanamide | 1432490-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3R,4R,5R)-N-(2-((3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)propyl)amino)ethyl)-2,3,5,6-tetrahydroxy-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanamide
• CAS: 1432490-50-0
• 化学式: C₂₄H₅₄N₂O₁₃Si₃
• 分子量: 662.955
• InChiKey: SSXYLEJGOFACLH-NUECYJFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.88
• 重原子数：
  42.0
• 可旋转键数：
  19.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  239.89
• 氢给体数：
  10.0
• 氢受体数：
  14.0

反应信息

• 作为产物：
  描述：

  N-(2-aminoethyl)-3-aminopropyltrisiloxane 、 乳糖酸 以 甲醇 为溶剂， 反应 24.0h， 以11.369 g的产率得到(2R,3R,4R,5R)-N-(2-((3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)propyl)amino)ethyl)-2,3,5,6-tetrahydroxy-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanamide
  参考文献：
  名称：

  Self-Assembly of Trisiloxane-Tailed Sugar Surfactant in Aqueous Solution

  摘要：

  A lactobionamide-based trisiloxane surfactant (Si3N2-LA) was prepared via a two-step method. Structure characterization of Si3N2-LA was performed by Fourier transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (H-1 NMR). Surface activity and aggregation behavior in aqueous solution of Si3N2-LA were investigated by surface tension measurements, dynamic light scattering (DLS) and negative-stained transmission electron microscopy (TEM). The results show that the surfactants can self-assemble into spherical vesicles with diameters in the range from 50 to 150nm due to the introduction of trisiloxane tail.

  DOI：

  10.1080/10426507.2012.700352