2,4'-dimethyl-[1,1'-biphenyl]-4-ol | 857783-93-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4'-dimethyl-[1,1'-biphenyl]-4-ol
• 英文别名: 4-Hydroxy-2.4'-dimethyl-biphenyl；3-Methyl-4-p-tolyl-phenol；2,4'-Dimethyl-biphenyl-4-ol；2,4'-Dimethyl[1,1'-biphenyl]-4-ol；3-methyl-4-(4-methylphenyl)phenol
• CAS: 857783-93-8
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: VMVPRJLGMLEHJI-UHFFFAOYSA-N

物化性质

• 沸点：
  225 °C(Press: 15 Torr)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,4'-dimethyl-[1,1'-biphenyl]-4-ol 在 potassium permanganate 、 alkaline solution 、 水 作用下， 生成 4-methoxy-biphenyl-2,4'-dicarboxylic acid
  参考文献：
  名称：

  Chatterjee, Journal of the Indian Chemical Society, 1935, vol. 12, p. 410,413

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲苯硼酸 、 4-碘-3-甲基苯酚 在 [PdCl(NNC^NHC-ⁿBu)]BF₄ caesium carbonate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以99%的产率得到2,4'-dimethyl-[1,1'-biphenyl]-4-ol
  参考文献：
  名称：

  Pyridyl-Supported Pyrazolyl−N-Heterocyclic Carbene Ligands and the Catalytic Activity of Their Palladium Complexes in Suzuki−Miyaura Reactions

  摘要：

  [GRAPHICS]Palladium complexes of two new types of unsymmetrical pyridyl-supported pyrazolyl-N-heterocyclic carbene ligands were synthesized and structurally characterized. A strategy to release the steric strain of the ligand was realized by the introduction of methylene linkers to the ligand molecule. All the palladium complexes exhibited good to excellent catalytic activity in Suzuki-Miyaura reactions of phenyl or p-tolylboronic acid with aryl halides including iodobenzene, aryl bromides, and activated aryl chlorides under mild conditions, revealing that the new ligands are promising for the construction of highly active transition-metal catalysts.

  DOI：

  10.1021/jo060795d

文献信息

• Persulfate-promoted synthesis of biphenyl compounds in water from biomass-derived triacetic acid lactone
  作者：Gilberto G. Duarte Ortin、Airton G. Salles

  DOI：10.1039/d2ob01900k

  日期：——

  A metal-free, persulfate-promoted route in water to access substituted biphenyl compounds is described. In our approach, the biomass-derived triacetic acid lactone (TAL) and phenylacetylenes are employed to generate targeted products in high yields and regioselectivity. The present method contributes to the green synthesis initiative to harness renewable biomass-derived compounds in environmentally

  描述了一种无金属、过硫酸盐促进的在水中获得取代联苯化合物的途径。在我们的方法中，生物质衍生的三乙酸内酯 (TAL) 和苯乙炔被用于以高产率和区域选择性生成目标产物。本方法有助于以环保方法利用可再生生物质衍生化合物的绿色合成计划。
• Efficient access to triphenylene derivatives via carbamate-directed bay-region selective arylation of biphenol derivatives and Scholl cyclization
  作者：Chuane Guo、Yunfeng Liu、Yang Liu、Hongbin Zhang、Dan Yi、Shuo Wang、Bi-Qin Wang、Shi-Kai Xiang、Yingbo Shi

  DOI：10.1016/j.tet.2024.133985

  日期：2024.5

  for carbamate-directed -C-H bond arylation of biphenyl derivatives employing diaryliodonium salts as the arylation agents was explored. Consequently, the Scholl reaction was utilized to cyclize the product, yielding 21 varieties of multifunctional triphenylene derivatives. The maximum yield achieved through this two-step process was 94 %, offering an efficient synthesis route for the production of multi-substituted

  探索了一种使用二芳基碘鎓盐作为芳基化剂的氨基甲酸酯导向的联苯衍生物-C-H键芳基化的新方法。因此，利用Scholl反应将产物环化，得到21种多官能苯并菲衍生物。通过该两步工艺实现的最大产率为 94%，为生产多取代苯并菲衍生物提供了一条有效的合成路线。
• Pyridyl-Supported Pyrazolyl−<i>N</i>-Heterocyclic Carbene Ligands and the Catalytic Activity of Their Palladium Complexes in Suzuki−Miyaura Reactions
  作者：Zeng、Yu

  DOI：10.1021/jo060795d

  日期：2006.7.1

  [GRAPHICS]Palladium complexes of two new types of unsymmetrical pyridyl-supported pyrazolyl-N-heterocyclic carbene ligands were synthesized and structurally characterized. A strategy to release the steric strain of the ligand was realized by the introduction of methylene linkers to the ligand molecule. All the palladium complexes exhibited good to excellent catalytic activity in Suzuki-Miyaura reactions of phenyl or p-tolylboronic acid with aryl halides including iodobenzene, aryl bromides, and activated aryl chlorides under mild conditions, revealing that the new ligands are promising for the construction of highly active transition-metal catalysts.
• Chatterjee, Journal of the Indian Chemical Society, 1935, vol. 12, p. 410,413
  作者：Chatterjee

  DOI：——

  日期：——