2,4-Dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-3-pyridinecarboxamide | 404875-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,4-Dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-3-pyridinecarboxamide
• 英文别名: 2,4-dichloro-N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]pyridine-3-carboxamide
• CAS: 404875-66-7
• 化学式: C₁₃H₇Cl₃F₃N₃O
• 分子量: 384.572
• InChiKey: JQRDBKCTCFNWFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4-二氯烟酸 、 2-(氨甲基)-3-氯-5-三氟甲基吡啶盐酸盐 、 三乙胺 在 silica gel 、 二氯甲烷 作用下， 以 氯化亚砜 、 二氯甲烷 为溶剂， 反应 17.0h， 以provided the title compound as a solid, m.p. 122-124° C.的产率得到2,4-Dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-3-pyridinecarboxamide
  参考文献：
  名称：

  Pyridinyl amides and imides for use as fungicides

  摘要：

  公开了化学式（I）的化合物，其N-氧化物和适用于农业的盐，可用作杀菌剂。其中，化学式（I）和（II）中，A是取代的吡啶环；B是取代的吡啶环；W是C=L或SOn，其中n是O或S；R1和R2分别独立地表示H；或C1-C6烷基，C2-C6烯基，C2-C6炔基或C3-C6环烷基，每种均可选地取代；R3表示H；或C1-C6烷基，C2-C6烯基，C2-C6炔基或C3-C6环烷基，C2-C6烷基羰基，C2-C6烷氧基羰基，C2-C6烷基氨基羰基或C3-C8双烷基氨基羰基；R4是C1-C6烷基，C2-C6烯基，C2-C6炔基或C3-C6环烷基，每种均可选地取代；X是O或S；n为1或2；但是当W为C═O且R1，R2和R3均为H时，B不是4-三氟甲基-3-吡啶基，2-氯-4-吡啶基和2,6-二卤代-4-吡啶基之一。还公开了含有化学式（I）的化合物的组合物，以及一种控制由真菌植物病原体引起的植物病害的方法，该方法涉及施用化学式（I）的化合物的有效量。

  公开号：

  US07074742B2

文献信息

• Synergistic fungicide compositions containing at least one n-(2-pyridinyl) 1-3-pyridinecarboxamide derivative and one or more further fungicides useful for controlling fungal plant diseases
  申请人：Foor Ray Stephen

  公开号：US20050009889A1

  公开（公告）日：2005-01-13

  Compositions for controlling plant diseases caused by fungal plant pathogens are described, comprising: (a) at least one compound of Formula I, including all geometric and stereoisomers, N-oxides and agriculturally suitable salts thereof: I—wherein R1, R 2 , R 5 and R 6 , m and n are as defined in the disclosure; and (b) at least one compound selected from the group consisting of (b1) alkylenebis(dithiocarbamate) fungicides; (b2) compounds acting at the bc 1 complex of the fungal mitochondrial respiratory electron transfer site; (b3) cymoxanil; (b4) compounds acting at the demethylase enzyme of the sterol biosynthesis pathway; (b5) morpholine and piperidine compounds that act on the sterol biosynthesis pathway; (b6) phenylamide fungicides; (b7) pyrimidinone fungicides; (b8) phthalimides; and (b9) fosetyl-aluminum. Also disclosed are methods for controlling plant diseases caused by fungal plant pathogens that involves applying an effective amount of the combinations described.

  本文描述了用于控制由真菌植物病原体引起的植物病害的组合物，包括：(a) 公式I中至少一种化合物，包括所有几何和立体异构体，N-氧化物及其农业适用的盐：I - 其中R1、R2、R5和R6、m和n如所述；以及(b) 从以下组中选择至少一种化合物：(b1) 烷基双硫代氨基甲酸盐类杀菌剂；(b2) 作用于真菌线粒体呼吸电子传递位点的bc1复合物的化合物；(b3) 西莫沙；(b4) 作用于甾醇生物合成途径的去甲基酶酶的化合物；(b5) 作用于甾醇生物合成途径的吗啉和哌啶化合物；(b6) 苯甲酰胺类杀菌剂；(b7) 嘧啶酮类杀菌剂；(b8) 邻苯二甲酰亚胺；以及(b9) 磷酸铝。还公开了控制由真菌植物病原体引起的植物病害的方法，该方法涉及施用所述组合物的有效量。
• PYRIDINYL AMIDES AND IMIDES FOR USE AS FUNGICIDES
  申请人：E. I. du Pont de Nemours and Company

  公开号：EP1322614A2

  公开（公告）日：2003-07-02
• US7074742B2
  申请人：——

  公开号：US7074742B2

  公开（公告）日：2006-07-11
• [EN] PYRIDINYL AMIDES AND IMIDES FOR USE AS FUNGICIDES<br/>[FR] PYRIDINYL-AMIDES ET PYRIDINYL-IMIDES UTILISÉS COMME FONGICIDES
  申请人：DU PONT

  公开号：WO2002022583A2

  公开（公告）日：2002-03-21

  Compounds of Formula (I), their N-oxides and agriculturally suitable salts are disclosed which are useful as fungicides formula (I), (II) wherein A is a substituted pyridinyl ring; B is a substituted pyridinyl ring; W is C=L or SOn is O or S; R?1 and R2¿ are each independently H; or C¿1?-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted; R?3¿ is H; or C¿1?-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkylaminocarbonyl or C3-C8 dialkylaminocarbonyl; R?4¿ is C1-C6 alkyl, C¿2?-C6 alkenyl, C2-C6 alkynyl or C3-C6 cycloalkyl, each optionally substituted; X is O or S; and n is 1 or 2; provided that when W is C=O and R?1, R2 and R3¿ are H; then B is other than 4-trifluoromethyl-3-pyridinyl, 2-chloro-4-pyridinyl and 2,6-dihalo-4-pyridinyl.Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling plant diseases caused by fungal plant pathogens that involves applying an effective amount of a compound of Formula (I).
• [EN] SYNERGISTIC FUNGICIDE COMPOSITIONS CONTAINING AT LEAST ONE N-`(2-PYRIDINYL)METHYL!-3-PYRIDINECARBOXAMIDE DERIVATIVE AND ONE OR MORE FURTHER FUNGICIDES USEFUL FOR CONTROLLING FUNGAL PLANT DISEASES<br/>[FR] COMPOSITIONS FONGICIDES SYNERGETIQUES CONTENANT AU MOINS UN DERIVE DE N-`(2-PYRIDINYL)METHYL-3-PYRIDINECARBOXAMIDE ET AU MOINS UN AUTRE FONGICIDE UTILISE POUR LUTTER CONTRE LES MYCOSES DES VEGETAUX
  申请人：——

  公开号：WO2003079787A9

  公开（公告）日：2004-02-12

  [EN] Compositions for controlling plant diseases caused by fungal plant pathogens are described, comprising:(a) at least one compound of Formula I, including all geometric and stereoisomers, N-oxides and agriculturally suitable salts thereof : I -wherein R1, R2, R5 and R6 , m and n are as defined in the disclosure; and(b) at least one compound selected from the group consisting of (b1) alkylenebis(dithiocarbamate) fungicides; (b2) compounds acting at the bc1 complex of the fungal mitochondrial respiratory electron transfer site; (b3) cymoxanil; (b4) compounds acting at the demethylase enzyme of the sterol biosynthesis pathway; (b5) morpholine and piperidine compounds that act on the sterol biosynthesis pathway; (b6) phenylamide fungicides; (b7) pyrimidinone fungicides; (b8) phthalimides; and (b9) fosetyl-aluminum.Also disclosed are methods for controlling plant diseases caused by fungal plant pathogens that involves applying an effective amount of the combinations described.
  [FR] L'invention concerne des compositions utilisées pour lutter contre les agents pathogènes mycosiques des végétaux. Ces compositions contiennent: (a) au moins un composé de formule (I), comprenant toute la géométrie et la stéréoisomérie, leurs N-oxydes et leurs sels convenant à l'agriculture, dans laquelle R<1>, R<2>, R<5> et R<6>, m et n sont tels que définis dans le descriptif; et (b) au moins un composé sélectionné dans le groupe constitué par des fongicides (b1) alkylènebis(dithiocarbamate); (b2) des composés agissant sur le complexe bc1 du site de transfert d'électron respiratoire mitochondrial; (b3) cymoxanil; (b4) composés agissant sur la déméthylase du processus de biosynthèse de stérol; (b5) composés de morpholine et pipéridine qui agissent sur le processus de biosynthèse de stérol; (b6) fongicides de phénylamide; (b7) fongicides de pyrimidinone; (b8) phthalimides; et (b9) fosetyl-aluminum. Par ailleurs, l'invention concerne des procédés de lutte contre les maladies végétales causées par des agents pathogènes mycosiques des végétaux qui consistent à appliquer une quantité efficace des ces combinaisons.