[(3-methylthiophen-2-yl)methyl]triphenylphosphonium bromide | 78519-04-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(3-methylthiophen-2-yl)methyl]triphenylphosphonium bromide
• 英文别名: (3-methyl-2-thenyl)triphenyl phosphonium bromide；[(3-Methylthiophen-2-yl)methyl](triphenyl)phosphanium bromide；(3-methylthiophen-2-yl)methyl-triphenylphosphanium;bromide
• CAS: 78519-04-7
• 化学式: Br*C₂₄H₂₂PS
• 分子量: 453.382
• InChiKey: GRUHMNYAAVMZIC-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(3-methylthiophen-2-yl)methyl]triphenylphosphonium bromide 在 sodium hydroxide 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 3.16h， 生成 (4R)-4-methyl-4-[2-(3-methylthiophen-2-yl)ethenyl]-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives

  摘要：

  We herein report an asymmetric synthesis of alpha,alpha-disubstituted alpha-amino alcohol derivatives 3, key intermediates of a novel immunomodulator, using enzymatic desymmetrization of 2-alkyl-2-tert-butoxycarbonylamino-1,3-propanediols 1a and 1b. This method makes it possible to prepare a chiral analogue of FTY720 4. These synthetic procedures allow for a broad structure variation in order to evaluate structure-activity relationships and the mechanism of action for sphingosine 1-phosphate-1 (SIP1) receptor agonist. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.10.007
• 作为产物：
  描述：

  (3-甲基噻吩-2-基)甲醇 、 三苯基膦氢溴酸盐 在 苯 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 [(3-methylthiophen-2-yl)methyl]triphenylphosphonium bromide
  参考文献：
  名称：

  Polyene compounds

  摘要：

  本发明揭示了一种用作抗肿瘤剂的新型9-取代或未取代噻吩基-3,7-二甲基-诺纳-2,4,6,8-四烯衍生物，以及它们的制备方法和新型中间体。

  公开号：

  US04061656A1

文献信息

• Furan and thiophene derivatives that activate human peroxisome profilerator activated receptors
  申请人：——

  公开号：US20040157890A1

  公开（公告）日：2004-08-12

  A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof, for the treatment of a hPPAR mediated disease or condition. 1

  化合物公式（I）或其药学上可接受的盐和溶剂，用于治疗hPPAR介导的疾病或病况。
• Synthesis of conjugated organic dyes containing alkyl substituted thiophene for solar cell
  作者：Sanghoon Kim、Hyunbong Choi、Chul Baik、Kihyung Song、Sang Ook Kang、Jaejung Ko

  DOI：10.1016/j.tet.2007.08.058

  日期：2007.11

  Three organic dyes, JK-41, JK-42, and JK-43 containing bis-dimethylfluoreneaniline and alkyl substituted thiophene unit are designed and synthesized. Under standard global AM 1.5 solar condition, the JK-41 sensitized cell gave a short circuit photocurrent density (J(sc)) of 15.23 mA cm(-2), open circuit voltage (V-oc) of 0.67 V, and a fill factor of 0.67, corresponding to an overall conversion efficiency eta of 7.69%. Molecular-orbital calculations of the three dyes suggest that the electron distribution moves from the aniline derivative to the cyanoacrylic acid moiety. We found that the power conversion efficiency was shown to be quite sensitive to the structural variations of alkyl substituted thiophene moiety. (C) 2007 Elsevier Ltd. All rights reserved.
• FURAN AND THIOPHENE DERIVATIVES THAT ACTIVATE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS
  申请人：Smithkline Beecham Corporation

  公开号：EP1392674B1

  公开（公告）日：2005-08-10
• US4061656A
  申请人：——

  公开号：US4061656A

  公开（公告）日：1977-12-06
• US4116975A
  申请人：——

  公开号：US4116975A

  公开（公告）日：1978-09-26