| 1245014-24-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1245014-24-7
• 化学式: C₁₅H₁₀F₃N₅O₃
• 分子量: 365.271
• InChiKey: MROKRARJQBEWKW-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 10% palladium on carbon 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

  摘要：

  6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile analogues were identified as potent and selective cathepsin S inhibitor against both purified enzyme and in human JY cell based cellular assays. This core has a very stable thio-trapping nitrile war-head in comparison with the well reported pyrimidine-2-carbonitrile cysteine cathepsin inhibitors. Compound 47 is also very potent in in vivo mouse spleenic Lip10 accumulation assays. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.072