AC-Val-ser-arg-arg-arg-NH2 | 1632243-07-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AC-Val-ser-arg-arg-arg-NH2
• 英文别名: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanamide
• CAS: 1632243-07-2
• 化学式: C₂₈H₅₅N₁₅O₇
• 分子量: 713.8
• InChiKey: ZPSIKZCGZCSUNF-HVTWWXFQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.8
• 重原子数：
  50
• 可旋转键数：
  24
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  402
• 氢给体数：
  13
• 氢受体数：
  10

文献信息

• Peptide compounds for suppressing inflammation
  申请人：Duke University

  公开号：US10280210B2

  公开（公告）日：2019-05-07

  Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.

  本文提供了具有载脂蛋白生物活性的多肽，以及包含这些多肽的组合物和药物制剂。本文公开的肽、组合物和方法具有广泛的应用，因为它们可用于治疗各种损伤、疾病、失调和临床适应症。
• PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION
  申请人：Duke University

  公开号：US20140315823A1

  公开（公告）日：2014-10-23

  Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods disclosed herein have broad applications as they can be used to treat a broad spectrum of injury, diseases, disorders, and clinical indications.
• US9303063B2
  申请人：——

  公开号：US9303063B2

  公开（公告）日：2016-04-05
• [EN] USE OF APOE MIMETIC PEPTIDES FOR REDUCING THE LIKELIHOOD OF EPILEPTOGENESIS<br/>[FR] UTILISATION DE PEPTIDES MIMÉTIQUES D'APOE POUR RÉDUIRE LA PROBABILITÉ D'ÉPILEPTOGENÈSE
  申请人：UNIV DUKE

  公开号：WO2018140563A1

  公开（公告）日：2018-08-02

  Provided herein is a method for reducing the likelihood of epileptogenesis in a subject (e.g., a subject at risk thereof), comprising administering to said subject (e.g., a human subject) an effective amount a peptide of Formula I, or a pharmaceutically acceptable salt thereof.