| 1244763-96-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• CAS: 1244763-96-9
• 化学式: C₂₅H₂₃F₃N₄O₄S
• 分子量: 532.543
• InChiKey: GLXPKGMVUBWMNR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  potassium cyanide 、 以 二甲基亚砜 为溶剂， 反应 0.12h， 生成
  参考文献：
  名称：

  2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors

  摘要：

  Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl) pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.049
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 在 对甲苯磺酸 作用下， 以 乙酸乙酯 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors

  摘要：

  Starting from previously disclosed equally potent cathepsin K and S inhibitor 4-propyl-6-(3-trifluoromethylphenyl) pyrimidine-2-carbonitrile 1, a novel 2-phenyl-9H-purine-6-carbonitrile scaffold was identified to provide potent and selective cathepsin S inhibitors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.049