3-Methyl-1-phenyl-5,6-dithiophen-2-ylpyridin-2-one | 1256971-20-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Methyl-1-phenyl-5,6-dithiophen-2-ylpyridin-2-one
• 英文别名: 3-methyl-1-phenyl-5,6-dithiophen-2-ylpyridin-2-one
• CAS: 1256971-20-6
• 化学式: C₂₀H₁₅NOS₂
• 分子量: 349.477
• InChiKey: JYFUKCSIKJVYKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-二(2-噻吩基)乙炔 、 N-苯基甲基丙烯酰胺 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 copper(II) acetate monohydrate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以53%的产率得到3-Methyl-1-phenyl-5,6-dithiophen-2-ylpyridin-2-one
  参考文献：
  名称：

  Synthesis of 2-Pyridones and Iminoesters via Rh(III)-Catalyzed Oxidative Coupling between Acrylamides and Alkynes

  摘要：

  Catalytic oxidative coupling between acrylamides and alkynes was achieved using 0.5 mol % loading of [RhCp*Cl-2](2) with Cu(OAc)(2) as an oxidant. 2-Pyridones, iminoesters, and substituted indoles could be obtained as a result of the electronic and steric effects of the substituents in the acrylamides.

  DOI：

  10.1021/ol102306c

文献信息

• Synthesis of 2-Pyridones and Iminoesters via Rh(III)-Catalyzed Oxidative Coupling between Acrylamides and Alkynes
  作者：Yan Su、Miao Zhao、Keli Han、Guoyong Song、Xingwei Li

  DOI：10.1021/ol102306c

  日期：2010.12.3

  Catalytic oxidative coupling between acrylamides and alkynes was achieved using 0.5 mol % loading of [RhCp*Cl-2](2) with Cu(OAc)(2) as an oxidant. 2-Pyridones, iminoesters, and substituted indoles could be obtained as a result of the electronic and steric effects of the substituents in the acrylamides.