sodium 4-(phenotiazin-10-yl)butane-1-sulfonate | 198403-06-4

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: sodium 4-(phenotiazin-10-yl)butane-1-sulfonate
• 英文别名: sodium 4-(phenothiazin-10-yl)butane-1-sulfonate；Sodium;4-phenothiazin-10-ylbutane-1-sulfonate
• CAS: 198403-06-4
• 化学式: C₁₆H₁₆NO₃S₂*Na
• 分子量: 357.43
• InChiKey: BEKUWWVVPNKBNT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  94.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase acitivity
  申请人：Della Ciana Leopoldo

  公开号：US20080176251A1

  公开（公告）日：2008-07-24

  A process is described for preparing, efficiently and with a high degree of purity N-alkylsulfonates of phenothiazine. The process consists in (a) the preparation of the phenothiazine anion, and (b) the reaction of said anion with cyclic alkyl sulfonates, such as 1,3-propane sultone and 1,4-butane sultone. This process is simpler, more direct, and more efficient than the procedures currently used for the synthesis of N-alkylsulfonates derivatives of phenothiazine. In addition, the products obtained with this process are far more pure than those obtained through current procedures and therefore ideal for bioanalytical applications that require high sensitivity, such as assays based on the measurement of peroxidase activity using chemiluminescence.

  描述了一种制备苯并噻嗪N-烷基磺酸盐的过程，高效且纯度较高。该过程包括(a)制备苯并噻嗪负离子，以及(b)将该负离子与环状烷基磺酸盐（如1,3-丙烷磺酸内酯和1,4-丁烷磺酸内酯）反应。这一过程比目前用于合成苯并噻嗪N-烷基磺酸盐衍生物的程序更简单、更直接、更高效。此外，用这一过程得到的产品比通过当前程序得到的产品更纯，因此非常适合需要高灵敏度的生物分析应用，如基于化学发光法测定过氧化物酶活性的分析。
• Reagent and kit for performing chemiluminescent reaction
  申请人：BIO-HELIX CO., LTD.

  公开号：US10711185B2

  公开（公告）日：2020-07-14

  A reagent for performing a chemiluminescent reaction includes luminol or luminol derivatives, an oxidant, an electron mediator, and an enhancer. The enhancer is a nitrogen-containing fused heterocyclic compound having at least two nitrogen atoms. The present disclosure further provides a kit for performing a chemiluminescent reaction comprising the aforesaid reagent.

  用于进行化学发光反应的试剂包括发光酚或发光酚衍生物、氧化剂、电子介质和增强剂。增强剂是一种含氮的融合杂环化合物，至少有两个氮原子。本公开进一步提供了一种用于进行化学发光反应的试剂盒，其中包含上述试剂。
• Reagent and kit for enhancing chemiluminescent reaction
  申请人：NATIONAL TAIWAN OCEAN UNIVERSITY

  公开号：US11112366B2

  公开（公告）日：2021-09-07

  A reagent for enhancing a chemiluminescent reaction includes luminol or luminol derivatives, an oxidant, an electron mediator, and an enhancer. The enhancer is a nitrogen-containing fused heterocyclic compound having at least two nitrogen atoms. The present disclosure further provides a kit for enhancing a chemiluminescent reaction comprising the foregoing reagent.

  一种用于增强化学发光反应的试剂包括发光酚或发光酚衍生物、氧化剂、电子介质和增强剂。增强剂是一种含氮的融合杂环化合物，至少有两个氮原子。本公开进一步提供了一种用于增强化学发光反应的试剂盒，包括上述试剂。
• Preparation of high purity phenothiazine n-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity
  申请人：Cyanagen Srl

  公开号：EP1950207B1

  公开（公告）日：2012-06-20
• REAGENT AND KIT FOR ENHANCING CHEMILUMINESCENT REACTION
  申请人：NATIONAL TAIWAN OCEAN UNIVERSITY

  公开号：US20200309707A1

  公开（公告）日：2020-10-01

  A reagent for enhancing a chemiluminescent reaction includes luminol or luminol derivatives, an oxidant, an electron mediator, and an enhancer. The enhancer is a nitrogen-containing fused heterocyclic compound having at least two nitrogen atoms. The present disclosure further provides a kit for enhancing a chemiluminescent reaction comprising the foregoing reagent.