(3S,4S)-1-benzyl-3-(N-tert-butoxycarbonyl)amino-4-methoxypyrrolidine | 174847-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,4S)-1-benzyl-3-(N-tert-butoxycarbonyl)amino-4-methoxypyrrolidine
• 英文别名: (+)-trans-1-benzyl-3-(t-butoxycarbonylamino)-4-methoxypyrrolidine；tert.-Butyl N-(trans-1-benzyl-4-methoxypyrrolidin-3yl)carbamate；tert-butyl N-[(3S,4S)-1-benzyl-4-methoxypyrrolidin-3-yl]carbamate
• CAS: 174847-50-8
• 化学式: C₁₇H₂₆N₂O₃
• 分子量: 306.405
• InChiKey: RVUGUSZSDYIZMS-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3S,4S)-1-benzyl-3-(N-tert-butoxycarbonyl)amino-4-methoxypyrrolidine 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 7.0h， 生成 (3S,4S)-3-(N-tert-butoxycarbonyl)methylamino-4-methoxypyrrolidine
  参考文献：
  名称：

  Practical synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine

  摘要：

  Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumor agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (+/-)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(01)00530-4
• 作为产物：
  描述：

  3-吡咯烷胺,4-甲氧基-1-(苯基甲基)-,(3R,4R)-rel- 在 L-酒石酸 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 (3S,4S)-1-benzyl-3-(N-tert-butoxycarbonyl)amino-4-methoxypyrrolidine
  参考文献：
  名称：

  Practical synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine

  摘要：

  Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumor agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (+/-)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(01)00530-4

文献信息

• 7-(1-pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid
  申请人：Bayer Aktiengesellschaft

  公开号：US04990517A1

  公开（公告）日：1991-02-05

  7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen, X.sup.2 is hydrogen, halogen, amino or other radical, R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical, R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical, R.sup.3 is ##STR2## A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1, and addition products thereof.

  7-(1-吡咯啉基)-3-喹啉基-和-萘啉基羧酸衍生物作为抗菌剂和饲料添加剂，其化学式为##STR1##其中X.sup.1为卤素，X.sup.2为氢、卤素、氨基或其他基团，R.sup.1为烷基、环烷基、可选择取代的苯基或其他基团，R.sup.2为氢、烷基或二氧杂环丙基基团，R.sup.3为##STR2##A为N、CH、C-卤素或类似物，或与R.sup.1形成桥梁的结合物。
• Compounds, processes for the preparation thereof and anti-tumor agents
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：US05817669A1

  公开（公告）日：1998-10-06

  This invention relates to pyridone-carboxylic acid derivatives of the following formula or salts thereof: ##STR1## wherein R.sub.1 is a hydrogen atom, a halogen atom, etc., R.sub.2 is a carboxyl group etc., R.sub.3 is a hydrogen atom etc., A is a nitrogen atom or CH, m is 1 or 2, and Y is an eliminable group or a group having the following formula: ##STR2## wherein R.sub.4 is a hydrogen atom or a lower alkyl group, Z is a hydrogen atom, a lower alkyl group, etc., R.sub.5 is a hydrogen atom, a lower alkyl group, etc., n is 0 or 1, and p is 1, 2, 3 or 4 and to processes for the preparation of these compounds, and further to anti-tumor agents which contain the above compounds as effective ingredients.

  本发明涉及具有以下通式的吡啶酮羧酸衍生物或其盐：##STR1##其中R1为氢原子、卤素原子等，R2为羧基等，R3为氢原子等，A为氮原子或CH，m为1或2，Y为可消除基团或具有以下通式的基团：##STR2##其中R4为氢原子或低级烷基，Z为氢原子、低级烷基等，R5为氢原子、低级烷基等，n为0或1，p为1、2、3或4，以及制备这些化合物的方法，并且进一步涉及含有上述化合物作为有效成分的抗肿瘤药物。
• NOVEL COMPOUND, PROCESS FOR PRODUCING THE SAME, AND ANTITUMOR AGENT
  申请人：DAINIPPON PHARMACEUTICAL CO., LTD.

  公开号：EP0787726B1

  公开（公告）日：2001-11-28
• US4990517A
  申请人：——

  公开号：US4990517A

  公开（公告）日：1991-02-05
• US5059597A
  申请人：——

  公开号：US5059597A

  公开（公告）日：1991-10-22