Methyl-<5-methyl-thienyl-(2)>-sulfoxyd | 98135-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Methyl-<5-methyl-thienyl-(2)>-sulfoxyd
• 英文别名: 2-Methyl-5-methylsulfinylthiophene
• CAS: 98135-82-1
• 化学式: C₆H₈OS₂
• 分子量: 160.261
• InChiKey: FTKOKRLDZCKQOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors
  申请人：Vicker Nigel

  公开号：US20090042929A1

  公开（公告）日：2009-02-12

  There is provided a compound having Formula (I) R 1 -Z-R 2 wherein R 1 is a group selected from optionally substituted fused polycyclic groups, substituted alkyl groups, branched alkyl groups, and optionally substituted cycloalkyl groups Z is a linker which is or comprises a carbonyl group or a isostere of a carbonyl group R 2 is selected from optionally substituted aromatic rings and optionally substituted heterocyclic rings wherein (a) R 2 is a 2-substituted thiophene group, and/or (b) Z is a group of the formula —C(═O)—CR 3 R 4 —X—(CR 5 R 6 )n-, wherein X is selected from NR 7 , S, O, S═O, and S(═O) 2 , wherein n is 0 or 1 and/or (c) R 1 is an adamantyl group and Z is or comprises an amide group, and/or (d) R 1 is an adamantyl group and Z is or comprises a group of the formula —(CR 8 R 9 )p-NR 10 —S(═O) 2 —(CR 11 R 12 )q-, wherein p is 0 or 1 and q is 0 or 1 and/or (e) R 1 is an adamantyl group and Z is or comprises a group of the formula —(CR 13 R 14 )V—Y—(CR 15 R 16 )W— where Y is a heteroaryl group in which a bond in the heteroaryl ring is a isostere of a carbonyl group, wherein v is o or 1 and w is 0 or 1; wherein each of R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , R 11 , R 12 , R 13 , R 14 , R 15 and R 16 , are independently selected from H, hydrocarbyl and halogen, wherein each of R 7 and R 10 are independently selected from H and hydrocarbyl.

  提供一种化合物，其化学式为(I) R1-Z-R2，其中R1是选自可选取代的融合多环基团、取代的烷基基团、支链烷基基团和可选取代的环烷基基团的基团；Z是一个连接基团，可以是或包含一个羰基基团或一个羰基基团的同分异构体；R2是选自可选取代的芳香环和可选取代的杂环；其中(a) R2是2-取代噻吩基团，和/或(b) Z是一个化学式为—C(═O)—CR3R4—X—(CR5R6)n-的基团，其中X选自NR7、S、O、S═O和S(═O)2，n为0或1，和/或(c) R1是一个金刚烷基团，Z是或包含一个酰胺基团，和/或(d) R1是一个金刚烷基团，Z是或包含一个化学式为—(CR8R9)p-NR10—S(═O)2—(CR11R12)q-的基团，其中p为0或1，q为0或1，和/或(e) R1是一个金刚烷基团，Z是或包含一个化学式为—(CR13R14)V—Y—(CR15R16)W—的基团，其中Y是一个杂环基团，在杂环环中的一个键是羰基基团的同分异构体，v为0或1，w为0或1；其中R3、R4、R5、R6、R8、R9、R11、R12、R13、R14、R15和R16各自独立地选自H、烃基和卤素，R7和R10各自独立地选自H和烃基。
• Compound
  申请人：Vicker Nigel

  公开号：US20100120789A1

  公开（公告）日：2010-05-13

  There is provided a compound having Formula I R 1 —Z—R 2 Formula I wherein R 1 is a group selected from optionally substituted fused polycyclic groups, substituted alkyl groups, branched alkyl groups, and optionally substituted cycloalkyl groups Z is a linker which is or comprises a carbonyl group or a isostere of a carbonyl group R 2 is selected from optionally substituted aromatic rings and optionally substituted heterocyclic rings wherein (a) R 2 is a 2-substituted thiophene group, and/or (b) Z is a group of the formula —C(═O)—CR 3 R 4 —X—(CR 5 R 6 )n-, wherein X is selected from NR 7 , S, O, S═O, and S(═O) 2 , wherein n is 0 or 1 and/or (c) R 1 is an adamantyl group and Z is or comprises an amide group, and/or (d) R 1 is an adamantyl group and Z is or comprises a group of the formula —(CR 8 R 9 )p- NR 10 —S(═O) 2 —(CR 11 R 12 )q-, wherein p is 0 or 1 and q is 0 or 1 and/or (e) R 1 is an adamantyl group and Z is or comprises a group of the formula —(CR 13 R 14 )v-Y—(CR 15 R 16 )w- where Y is a heteroaryl group in which a bond in the heteroaryl ring is a isostere of a carbonyl group, wherein v is o or 1 and w is 0 or 1; wherein each of R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , R 11 , R 12 , R 13 , R 14 , R 15 and R 16 , are independently selected from H, hydrocarbyl and halogen, wherein each of R 7 and R 10 are independently selected from H and hydrocarbyl.

  提供了一种具有IR1-Z-R2式的化合物，其中： R1是从可选取代的融合多环基团，取代的烷基基团，分支烷基基团和可选取代的环烷基基团中选择的基团； Z是或包括一个羰基或羰基的同分异构体的连接基团； R2是从可选取代的芳香环和可选取代的杂环中选择的基团，其中 (a) R2是2-取代噻吩基团，和/或 (b) Z是公式-C（═O）-CR3R4-X-（CR5R6）n-的基团，其中X从NR7，S，O，S═O和S（═O）2中选择，n为0或1，和/或 (c) R1是金刚烷基团，Z是或包括酰胺基团，和/或 (d) R1是金刚烷基团，Z是或包括公式-CR8R9p-NR10-S（═O）2-（CR11R12）q-的基团，其中p为0或1，q为0或1，和/或 (e) R1是金刚烷基团，Z是或包括公式（CR13R14）v-Y-（CR15R16）w-的基团，其中Y是杂环基团，其中杂环环中的一个键是羰基的同分异构体，v为0或1，w为0或1； 其中R3，R4，R5，R6，R8，R9，R11，R12，R13，R14，R15和R16中的每一个独立选择自H，烃基和卤素，其中R7和R10各自独立选择自H和烃基。