2-Nitro-3-carboxythiophenol | 111853-16-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Nitro-3-carboxythiophenol
• 英文别名: Thio-2-nitrobenzoic acid；2-nitro-3-sulfanylbenzoic acid
• CAS: 111853-16-8
• 化学式: C₇H₅NO₄S
• 分子量: 199.187
• InChiKey: DUFIJRYDTNSZQY-UHFFFAOYSA-N

物化性质

• 沸点：
  398.5±37.0 °C(Predicted)
• 密度：
  1.575±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Nitro-3-carboxythiophenol 在 氯化亚砜 、 三乙胺 、 sodium phosphate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2,4-Dinitro-5-benzyloxy-3-chlorocarbonylphenyl 2-nitro-3-chlorocarbonylphenyl sulfide
  参考文献：
  名称：

  Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. F., Journal of Organic Chemistry USSR (English Translation), 1987, vol. 23, p. 585 - 592

  摘要：

  DOI：

文献信息

• Mediators of hedgehog signaling pathways, compositions and uses related thereto
  申请人：Guicherit M. Oivin

  公开号：US20070021493A1

  公开（公告）日：2007-01-25

  The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

  本发明提供了一种抑制由于刺猬基因增强作用导致的异常生长状态的方法和试剂，通过使用刺猬拮抗剂（如小分子）与细胞接触，以足够的剂量来抑制异常生长状态，例如激活正常的ptc通路或拮抗刺猬活性。
• METHOD OF MEASURING ACTIVITY OF HOMOCYSTEINE THIOLACTONE HYDROLASE
  申请人：Alfresa Pharma Corporation

  公开号：EP1739188A1

  公开（公告）日：2007-01-03

  Disclosed is a method for measurement of the activity of the homocysteinethiolactone hydrolyzing enzyme in a sample, which method comprises mixing and reacting γ-thiobutyrolactone and the sample in the presence of a cholinesterase inhibitor, and measuring 4-mercaptobutyric acid thereby produced. The method is safe and easy in operation, for it does not use a radioactive substrate, and is free of the influence of other compounds occurring in a sample from the body.

  本发明公开了一种测量样品中同型半胱氨酸硫内酯水解酶活性的方法，该方法包括在胆碱酯酶抑制剂存在的情况下，将γ-硫代丁酸内酯和样品混合并发生反应，然后测量由此产生的 4-巯基丁酸。该方法不使用放射性底物，不受人体样本中其他化合物的影响，操作安全简便。
• SEMICONDUCTOR DEVICE HAVING QUANTUM DOTS
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP3859804A2

  公开（公告）日：2021-08-04

  A semiconductor device includes an anode (131), a cathode (134), a first functional layer (133B) between the anode and cathode, and a second functional layer (133C) between the first functional layer and the cathode. The first functional layer contains a first quantum dot having a first ligand, and the second functional layer contains a second quantum dot having a second ligand different from the first ligand. The second ligand is an aromatic compound having a sulfide bond and an ester bond.

  一种半导体器件包括阳极（131）、阴极（134）、阳极和阴极之间的第一功能层（133B）以及第一功能层和阴极之间的第二功能层（133C）。第一功能层包含具有第一配体的第一量子点，第二功能层包含具有不同于第一配体的第二配体的第二量子点。第二配体是具有硫化键和酯键的芳香族化合物。
• Sevbo,D.P. et al., Journal of Organic Chemistry USSR (English Translation), 1977, vol. 13, p. 144 - 148
  作者：Sevbo,D.P. et al.

  DOI：——

  日期：——
• Method for Measurement of Activity of Homocysteinethiolactone Hydrolyzing Enzyme
  申请人：Yamaguchi Masahiro

  公开号：US20070243571A1

  公开（公告）日：2007-10-18

  Disclosed is a method for measurement of the activity of the homocysteinethiolactone hydrolyzing enzyme in a sample, which method comprises mixing and reacting γ-thiobutyrolactone and the sample in the presence of a cholinesterase inhibitor, and measuring 4-mercaptobutyric acid thereby produced. The method is safe and easy in operation, for it does not use a radioactive substrate, and is free of the influence of other compounds occurring in a sample from the body.