(+/-) Ethyl 2-{4-[2-(2-ethyl-6-oxo-4-phenyl-1,6-dihydropyrimidin-1-yl)ethoxy]phenoxy}-2-methyl propanoate | 471906-32-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (+/-) Ethyl 2-{4-[2-(2-ethyl-6-oxo-4-phenyl-1,6-dihydropyrimidin-1-yl)ethoxy]phenoxy}-2-methyl propanoate
• 英文别名: Ethyl 2-[4-[2-(2-ethyl-6-oxo-4-phenylpyrimidin-1-yl)ethoxy]phenoxy]-2-methylpropanoate
• CAS: 471906-32-8
• 化学式: C₂₆H₃₀N₂O₅
• 分子量: 450.535
• InChiKey: NSVXHXDZFAQLEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-(2-chloroethyl)-2-ethyl-4-phenyl-1,6-dihydropyrimidin-6-one 、 ethyl-2-methyl-4-hydroxy phenoxy propanoate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (+/-) Ethyl 2-{4-[2-(2-ethyl-6-oxo-4-phenyl-1,6-dihydropyrimidin-1-yl)ethoxy]phenoxy}-2-methyl propanoate
  参考文献：
  名称：

  New monocyclic derivatives of aryl alkanoic acids and their use in medicine: process for their preparation and pharmaceutical compositions containing them

  摘要：

  本发明涉及新型的降血脂、抗高血糖化合物，它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。更具体地说，本发明涉及一般式（I）的新型β-芳基-α-氧基取代烷基羧酸、其衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。1

  公开号：

  US20030013729A1

文献信息

• US7348334B2
  申请人：——

  公开号：US7348334B2

  公开（公告）日：2008-03-25
• [EN] DERIVATIVES OF ARYL ACIDS, THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES D'ACIDES ARYLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CES DERIVES ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS DERIVES
  申请人：REDDYS LAB LTD DR

  公开号：WO2002081454A1

  公开（公告）日：2002-10-17

  The present invention relates to novel hypolipidemic, antihyperglycemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel b-aryl-a-oxysubstituted alkylcarboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. (Formula I).