4-(3-methoxy-4-pyrimidin-2-yl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester | 1093064-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(3-methoxy-4-pyrimidin-2-yl-phenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 4-(3-methoxy-4-(pyrimidin-2-yl)phenyl)-3,6-dihydropyridine-1(2H)-carboxylate；tert-butyl 4-(3-methoxy-4-pyrimidin-2-ylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylate
• CAS: 1093064-88-0
• 化学式: C₂₁H₂₅N₃O₃
• 分子量: 367.448
• InChiKey: MDTPGRDMXVUHPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel compounds that are ERK inhibitors
  申请人：Cooper Alan B.

  公开号：US20090118284A1

  公开（公告）日：2009-05-07

  Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

  本发明公开了式1.0的ERK抑制剂及其药学上可接受的盐、酯和溶剂化物。其中，Q是一个带有桥或融合环的哌啶或哌嗪环。哌啶环中可以在环上具有双键。所有其他取代基如本文所定义。本发明还公开了使用式1.0的化合物治疗癌症的方法。
• HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS
  申请人：Sun Robert

  公开号：US20110038876A1

  公开（公告）日：2011-02-17

  Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

  本发明涉及公开的ERK抑制剂，其化学式为1.0：[Formula (1.0)]及其药学上可接受的盐、酯和溶剂化物。其中，Q是一个可具有桥或融合环的哌啶或哌嗪环。哌啶环中可以在环中具有双键。所有其他取代基均如所定义。本发明还公开了使用化合物1.0治疗癌症的方法。
• POLYCYCLIC INDAZOLE DERIVATIVES AND THEIR USE AS ERK INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Schering Corporation

  公开号：EP2155722A1

  公开（公告）日：2010-02-24
• US8546404B2
  申请人：——

  公开号：US8546404B2

  公开（公告）日：2013-10-01
• [EN] HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION EN TANT QU'INHIBITEURS D'ERK
  申请人：SCHERING CORP

  公开号：WO2008156739A1

  公开（公告）日：2008-12-24

  [EN] Disclosed are the ERK inhibitors of formula 1.0: [Formula (1.0)] and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
  [FR] L'invention concerne des inhibiteurs d'ERK représentés par la formule 1.0 : [Formule (1.0)] et des sels, des esters et des solvates pharmaceutiquement acceptables de ceux-ci. Q est un cycle pipéridine ou pipérazine susceptible de posséder un pont ou un cycle condensé. Le cycle pipéridine peut comporter une double liaison. Tous les autres substituants sont tels que définis ici. L'invention concerne également des procédés destinés à traiter le cancer utilisant les composés représentés par la formule 1.0.