(3aR,4R,6S,7aR)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carboxylic acid ethyl ester | 131389-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: (3aR,4R,6S,7aR)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carboxylic acid ethyl ester
• CAS: 131389-49-6
• 化学式: C₂₁H₃₄O₉
• 分子量: 430.496
• InChiKey: QCGMVOTYIFBUPF-OZTWYZHESA-N

反应信息

• 作为反应物：
  描述：

  (3aR,4R,6S,7aR)-4-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-6-(2-ethoxycarbonyl-ethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-carboxylic acid ethyl ester 在 三氟乙酸 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 (2S,4R,5R,6R)-2-(2-Carboxy-ethyl)-6-((R)-1,2-dihydroxy-ethyl)-4,5-dihydroxy-tetrahydro-pyran-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of C-(β-d-glycosyl) analogues of 3-deoxy-d-manno-2-octulosonic acid (Kdo) as potential inhibitors of CMP-Kdo synthetase

  摘要：

  Eight C-(beta-D-glycosyl) analogues (14-21) of Kdo (3-deoxy-D-manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.

  DOI：

  10.1016/0008-6215(90)80066-c