Cinchonan-9-ol, 10,11-dihydro-6a(2)-methoxy-, 9-(N-2-propen-1-ylcarbamate), (9R)- | 313678-38-5

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: Cinchonan-9-ol, 10,11-dihydro-6a(2)-methoxy-, 9-(N-2-propen-1-ylcarbamate), (9R)-
• 英文别名: [(R)-[(2S,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methyl] N-prop-2-enylcarbamate
• CAS: 313678-38-5
• 化学式: C₂₄H₃₁N₃O₃
• 分子量: 409.5
• InChiKey: DQTWGXZHWGJQEF-BSWISCRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• LIQUID PHASE SEPARATION OF PLASMID DNA ISOFORMS AND TOPOISOMERS
  申请人：LAEMMERHOFER Michael

  公开号：US20120220729A1

  公开（公告）日：2012-08-30

  The invention relates to the use of material comprising a carbamoyl-decorated anion-exchanger ligand wherein a cationic group (C), and a hydrogen donor group (N—H), are connected by a spacer with a length between 3 to 5 atoms, immobilized onto or embedded into a heterogeneous matrix, for the separation of isoforms, topoisomers, oligomeric and multimeric forms of plasmid DNA (pDNA).

  本发明涉及使用一种包含氨基甲酰修饰的阴离子交换配体材料，其中阳离子基团（C）和氢供体基团（N-H）通过长度在3到5个原子之间的间隔连接，固定在或嵌入到异质基质中，用于分离质粒DNA（pDNA）的异构体、拓扑异构体、寡聚体和多聚体形式。
• [EN] LIQUID PHASE SEPARATION OF PLASMID DNA ISOFORMS AND TOPOISOMERS<br/>[FR] SÉPARATION EN PHASE LIQUIDE D'ISOFORMES ET DE TOPOISOMÈRES D'UN ADN PLASMIDIQUE
  申请人：BOEHRINGER INGELHEIM RCV GMBH

  公开号：WO2012116945A2

  公开（公告）日：2012-09-07

  The invention relates to the use of material comprising a carbamoyl-decorated anion-exchanger ligandwherein a cationic group (C), and a hydrogen donor group (N-H), are connected by a spacer with a length between 3 to 5 atoms, immobilized onto or embedded into a heterogeneous matrix, for the separation of isoforms, topoisomers, oligomeric and multimeric forms of plasmid DNA (p DNA).