2',5'-dideoxy-3'-benzoyl-uridine | 158227-02-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物
• 英文名称: 2',5'-dideoxy-3'-benzoyl-uridine
• CAS: 158227-02-2
• 化学式: C₁₆H₁₆N₂O₅
• 分子量: 316.313
• InChiKey: NZUZVETVHLPKPG-SCDSUCTJSA-N

物化性质

• 密度：
  1.381±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  23.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  90.39
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2',5'-dideoxy-3'-benzoyl-uridine 在 hydroxide 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  5′-5′ tethered oligonucleotides via nucleic bases: A potential new set of compounds for alternate strand triple-helix formation

  摘要：

  The solid-phase synthesis of 5'-5'-linked oligonucleotides tethered via nucleic bases and with opposite polarities has been performed using a modified dinucleoside bearing a phosphoramidite group at the 3'-position of one nucleoside and a dimethoxytrityl group at the 3'-position of the second nucleoside.

  DOI：

  10.1016/s0040-4039(00)77068-7
• 作为产物：
  描述：

  2-脱氧尿苷 以 吡啶 为溶剂， 生成 2',5'-dideoxy-3'-benzoyl-uridine
  参考文献：
  名称：

  5′-5′ tethered oligonucleotides via nucleic bases: A potential new set of compounds for alternate strand triple-helix formation

  摘要：

  The solid-phase synthesis of 5'-5'-linked oligonucleotides tethered via nucleic bases and with opposite polarities has been performed using a modified dinucleoside bearing a phosphoramidite group at the 3'-position of one nucleoside and a dimethoxytrityl group at the 3'-position of the second nucleoside.

  DOI：

  10.1016/s0040-4039(00)77068-7

文献信息

• Synthesis of Nucleosides and Deoxynucleosides via Gold(I)-Catalyzed <i>N</i>-Glycosylation of Glycosyl (<i>Z</i>)-Ynenoates
  作者：Rongkun Liu、Yan Chen、Jibin Zheng、Lvfeng Zhang、Tong Xu、Peng Xu、You Yang

  DOI：10.1021/acs.orglett.2c03964

  日期：2022.12.30

  with purines was found to be very effective for regioselective synthesis of pyranosyl N9 purine nucleosides. Based on the catalytic N-glycosylation approach, convenient synthesis of two 5′-deoxynucleosides drugs (capecitabine and galocitabine), four 2′-deoxynucleoside drugs (floxuridine, trifluridine, decitabine and cladribine), four 3′,5′-dideoxynucleoside analogues, and four 2′,5′-dideoxynucleoside

  核苷类似物广泛用作抗癌和抗病毒药物。在这里，我们开发了一种高效的金（I）催化的N-糖基化方法，用于以糖基（Z）-炔酸作为供体合成各种类型的核苷和脱氧核苷。31 个嘧啶核苷和 8 个嘌呤核苷的合成证明了N-糖基化方法的广泛范围。值得注意的是，金（I）催化的吡喃糖基（Z ）-炔酸酯与嘌呤的N-糖基化被发现对于吡喃糖基N9嘌呤核苷的区域选择性合成非常有效。基于催化N-糖基化方法，方便合成两种5'-脱氧核苷药物（卡培他滨和加西他滨）、四种2'-脱氧核苷药物（氟尿苷、三氟尿苷、地西他滨和克拉屈滨）、四种3',5'-双脱氧核苷类似物，并集体获得了4个2',5'-双脱氧核苷类似物。
• Oligodeoxyribonucleotides Covalently Linked via Nucleic Bases with 3'-5' and 5'-5' Polarities
  作者：Ulysse Asseline、N. T. Thuong

  DOI：10.1080/15257779508012496

  日期：1995.5.1

  The solid-phase preparation of oligodeoxyribonucleotides covalently linked via nucleic bases with normal (3'-5') or inverted (5'-5') polarities is reported. The key-step of these syntheses is the preparation of the tethered dimers.
• CN115850356
  申请人：——

  公开号：——

  公开（公告）日：——