| 862674-27-9

• 分子结构分类: 有机化合物
• CAS: 862674-27-9
• 化学式: C₁₀₉H₁₃₆N₄O₂₄
• 分子量: 1886.29
• InChiKey: AECLAFOTADEQAU-ZVCLZFIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.99
• 重原子数：
  137.0
• 可旋转键数：
  45.0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  322.36
• 氢给体数：
  3.0
• 氢受体数：
  24.0

反应信息

• 作为反应物：
  描述：

  、 三氟乙酸 以 水 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  A simple strategy for the synthesis of the glycosylated collagen biomarkers α-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), α-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl

  摘要：

  A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.10.037
• 作为产物：
  描述：

  tert-butyl (2S,5S)-6-amino-2-benzyloxycarbonylamino-5-[(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyloxy)-(1->2)-(3,4,6-tri-O-benzyl-β-D-galactopyranosyloxy)]hexanoate 、 (S)-6-bromo-2-tert-butoxycarbonylamino-5-oxohexanoic acid tert-butyl ester 在 sodium carbonate 、 氧气 作用下， 以 乙腈 、 甲醇 为溶剂， 反应 80.0h， 以61%的产率得到
  参考文献：
  名称：

  A simple strategy for the synthesis of the glycosylated collagen biomarkers α-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-O-pyridinoline (Glc-Gal-PYD), α-d-glucopyranosyl-(1→2)-β-d-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their unnatural epimers Glc-Gal-epiPYD and Glc-Gal-epiHyl

  摘要：

  A short synthetic strategy for the preparation of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-O-pyridinoline (Glc-Gat-PYD), of the alpha-D-glucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-5-O-hydroxylysine (Glc-Gal-Hyl) and of their respective epimers, Glc-Gal-epiPYD and Glc-Gal-epiHyl, useful for the analytical evaluation of collagen biomarkers in human sinovium and bone, is reported. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.10.037