4-乙基-N-[2-羟基-1-(3,4,5-三羟基-6-甲硫基四氢吡喃-2-基)丙基]-1-甲基吡咯烷-2-甲酰胺 | 2520-24-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-乙基-N-[2-羟基-1-(3,4,5-三羟基-6-甲硫基四氢吡喃-2-基)丙基]-1-甲基吡咯烷-2-甲酰胺
• 中文别名: 林可霉素杂质B
• 英文名称: lincomycin B
• 英文别名: (2S,4R)-4-ethyl-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methylpyrrolidine-2-carboxamide
• CAS: 2520-24-3
• 化学式: C₁₇H₃₂N₂O₆S
• 分子量: 392.517
• InChiKey: DZSDDKNXMARQMJ-AVXYAQEDSA-N

物化性质

• 沸点：
  640.8±55.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)
• 溶解度：
  甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  148
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  D-葡萄糖 以 水 为溶剂， 反应 2.0h， 生成 4-乙基-N-[2-羟基-1-(3,4,5-三羟基-6-甲硫基四氢吡喃-2-基)丙基]-1-甲基吡咯烷-2-甲酰胺
  参考文献：
  名称：

  Biosynthesis of the lincomycins. 1. Studies using stable isotopes on the biosynthesis of the propyl- and ethyl-L-hygric acid moieties of lincomycins A and B

  摘要：

  DOI：

  10.1021/ja00337a038

文献信息

• [EN] ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE<br/>[FR] CONJUGUÉS ANIONIQUES D'UN MÉTABOLITE BACTÉRIEN GLYCOSYLÉ
  申请人：GLYCAN BIOSCIENCES PTY LTD

  公开号：WO2010037179A1

  公开（公告）日：2010-04-08

  The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.

  该发明涉及与糖基化细菌代谢产物的阴离子结合物，可用于模拟被称为糖胺聚糖（GAGs）的阴离子生物活性分子的结构和/或活性。该发明还涉及制备这些结合物的过程。这些结合物在预防和/或治疗疾病条件方面具有用处，特别是慢性疾病条件，如炎症（包括过敏）疾病、转移性癌症和感染病原体（包括细菌、病毒或寄生虫）的情况。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• ANIONIC CONJUGATES OF GLYCOSYLATED BACTERIAL METABOLITE
  申请人：Glycan Biosciences Pty Ltd

  公开号：EP2421877A1

  公开（公告）日：2012-02-29
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：enEvolv, Inc.

  公开号：EP3027754A1

  公开（公告）日：2016-06-08
• Anionic Conjugates of Glycosylated Bacterial Metabolite
  申请人：GLYCAN BIOSCIENCES LLC

  公开号：US20140323422A1

  公开（公告）日：2014-10-30

  The invention relates to anionic conjugates of glycosylated bacterial metabolites that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs). The invention also relates to processes for the preparation of the conjugates. Such conjugates are useful in the prophylaxis and/or treatment of disease conditions and in particular chronic disease conditions such as inflammatory (including allergic) diseases, metastatic cancers and infection by pathogenic agents including bacteria, viruses or parasites.