5-[4-[3-(3,4-difluorophenyl)-2-oxooxazolidin-5-yl]-methoxy]benzyl-2,4-thiazolidinedione | 168190-63-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[4-[3-(3,4-difluorophenyl)-2-oxooxazolidin-5-yl]-methoxy]benzyl-2,4-thiazolidinedione
• 英文别名: 5-[[4-[[3-(3,4-Difluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• CAS: 168190-63-4
• 化学式: C₂₀H₁₆F₂N₂O₅S
• 分子量: 434.42
• InChiKey: RBHHVEAAEGFOCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Methods and pharmaceutical compositions for inhibiting tumour cell growth
  申请人：DANA-FARBER CANCER INSTITUTE

  公开号：EP1410799A1

  公开（公告）日：2004-04-21

  Methods for inhibiting proliferation of a PPARγ-responsive hyperproliferative cell using PPARγ agonists are described. Pharmaceutical compositions as well as method for diagnosing and treating a PPARγ-responsive hyperproliferative cell are also described.

  描述了使用 PPARγ 激动剂抑制 PPARγ 反应性高增殖细胞增殖的方法。还描述了药物组合物以及诊断和治疗 PPARγ 反应性高增殖细胞的方法。
• METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING TUMOR CELL GROWTH
  申请人：Dana-Farber Cancer Institute

  公开号：US20020006950A1

  公开（公告）日：2002-01-17

  The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.

  本发明的基础是发现 PPAR&ggr; 的激活在诱导某些活跃增殖细胞的生长停滞和分化方面起着关键作用。我们的研究表明，服用 PPAR&ggr; 激动剂，如噻唑烷二酮配体（TZDs），在体外和体内都能有效抑制这类细胞的增殖。
• PAX8-PPARgamma nucleic acid molecules and polypeptides and uses thereof
  申请人：——

  公开号：US20020106796A1

  公开（公告）日：2002-08-08

  An oncogene designated PAX8-PPAR&ggr;1 contains a PAX8 coding region fused to PPAR&ggr; coding region. Molecular characterization of PAX8-PPAR&ggr;1 molecules provides nucleotide and amino acid sequences useful for detection and treatment of certain tumors, particularly thyroid follicular carcinomas.

  一种被命名为 PAX8-PPAR&ggr;1 的癌基因包含一个与 PPAR&ggr; 编码区融合的 PAX8 编码区。PAX8-PPAR&ggr;1 分子的分子特征提供了核苷酸和氨基酸序列，有助于检测和治疗某些肿瘤，特别是甲状腺滤泡癌。
• Methods and pharmaceutical compositions for inhibiting tumor cell growth
  申请人：——

  公开号：US20030144330A1

  公开（公告）日：2003-07-31

  The present invention is based on the finding that activation of PPAR&ggr; plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR&ggr; agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proiferation of such cells.

  本发明的基础是发现 PPAR&ggr; 的激活在诱导某些活跃增殖细胞的生长停滞和分化方面起着关键作用。我们的研究表明，服用 PPAR&ggr; 激动剂，如噻唑烷二酮配体（TZDs），在体外和体内都能有效抑制这类细胞的增殖。
• Methods and compositions for regulating adiopocytes
  申请人：——

  公开号：US20040171533A1

  公开（公告）日：2004-09-02

  The present application relates to a method for modulating the formation and/or maintenance of adipocyte tissue by ectopically contacting adipocyte cells, especially adipocyte stem/progenitor cells, in vitro or in vivo, with a hedgehog therapeutic or ptc therapeutic in an amount effective to alter the growth state the treated cells, e.g., relative to the absence of administeration of the hedgehog therapeutic or ptc therapeutic.

  本申请涉及一种调节脂肪细胞组织的形成和/或维持的方法，其方法是在体外或体内使脂肪细胞，特别是脂肪细胞干/祖细胞与刺猬治疗剂或ptc治疗剂异位接触，接触量应能有效改变所处理细胞的生长状态，例如，相对于未施用刺猬治疗剂或ptc治疗剂的情况。