2-hydroxy-2-(hydroxyphenylmethyl)indan-1-one | 1350912-95-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-hydroxy-2-(hydroxyphenylmethyl)indan-1-one
• 英文别名: 2-hydroxy-2-[hydroxy(phenyl)methyl]-3H-inden-1-one
• CAS: 1350912-95-6
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: ABPGBHFUGWHIOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (E)-2-benzylidene-2,3-dihydro-1H-inden-1-one 在 Eutypa lata 作用下， 以 乙醇 为溶剂， 反应 192.0h， 以5 mg的产率得到(1S,2R)-2-benzylindan-1-ol
  参考文献：
  名称：

  Asymmetric microbial conversion of (E)-2-benzylideneindan-1-one by the filamentous fungi Botrytis cinerea, Trichoderma viride, and Eutypa lata

  摘要：

  The transformation of (E)-2-benzylideneindan-1-one 1 by the filamentous fungi Bontrytis cinerea, Trichoderma viride, and Eutypa Iota as biocatalysts was studied. The results showed the catalytic potential of these fungi in affording several hydroxylation and reduction products, three of them reported here for the first time. The absolute configuration of enantiomerically pure 2-benzylindane derivatives was determined. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2011.09.010

文献信息

• Asymmetric microbial conversion of (E)-2-benzylideneindan-1-one by the filamentous fungi Botrytis cinerea, Trichoderma viride, and Eutypa lata
  作者：Cristina Pinedo-Rivilla、Josefina Aleu、Isidro G. Collado

  DOI：10.1016/j.tetasy.2011.09.010

  日期：2011.9

  The transformation of (E)-2-benzylideneindan-1-one 1 by the filamentous fungi Bontrytis cinerea, Trichoderma viride, and Eutypa Iota as biocatalysts was studied. The results showed the catalytic potential of these fungi in affording several hydroxylation and reduction products, three of them reported here for the first time. The absolute configuration of enantiomerically pure 2-benzylindane derivatives was determined. (C) 2011 Elsevier Ltd. All rights reserved.