5-Chloro-1,3-difluoro-2-(propan-2-yloxy)benzene | 1395038-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-Chloro-1,3-difluoro-2-(propan-2-yloxy)benzene
• 英文别名: 5-chloro-1,3-difluoro-2-propan-2-yloxybenzene
• CAS: 1395038-96-6
• 化学式: C₉H₉ClF₂O
• 分子量: 206.61
• InChiKey: PUGDMVABRZNJOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF
  申请人：Karyopharm Therapeutics Inc.

  公开号：US20190002448A1

  公开（公告）日：2019-01-03

  The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (I) or (II), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.