{4H,5H,6H-cyclopenta[b]thiophen-2-ylmethyl}({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine | 1401028-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: {4H,5H,6H-cyclopenta[b]thiophen-2-ylmethyl}({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl]ethyl})amine
• 英文别名: N-(5,6-dihydro-4H-cyclopenta[b]thiophen-2-ylmethyl)-2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine
• CAS: 1401028-40-7
• 化学式: C₂₄H₃₂N₂OS
• 分子量: 396.597
• InChiKey: BHYNUBAFYOYHAH-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2,6-DIOXASPIRO [4,5] DECANE DERIVATIVES AND PREPARATION METHOD THEREFOR AND PHARMACEUTICAL APPLICATIONS THEREOF
  申请人：SHANDONG LUYE PHARMACEUTICAL CO., LTD.

  公开号：US20200255444A1

  公开（公告）日：2020-08-13

  The present invention relates to a series of 2,6-dioxaspiro [4,5] decane derivatives and applications thereof in preparation of opiate receptor p agonist related drugs; and in particular relates to the derivative compounds shown in formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

  本发明涉及一系列2,6-二氧杂螺[4,5]癸烷衍生物及其在制备阿片受体P激动剂相关药物中的应用；特别涉及式(I)所示的衍生物化合物，其互变异构体或其药学上可接受的组合物。
• 2,6-dioxaspiro [4,5] decane derivatives and preparation method therefor and pharmaceutical applications thereof
  申请人：SHANDONG LUYE PHARMACEUTICAL CO., LTD.

  公开号：US11124523B2

  公开（公告）日：2021-09-21

  The present invention relates to a series of 2,6-dioxaspiro [4,5] decane derivatives and applications thereof in preparation of opiate receptor μ agonist related drugs; and in particular relates to the derivative compounds shown in formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.

  本发明涉及一系列2,6-二氧杂螺[4,5]癸烷衍生物及其在制备阿片受体μ激动剂相关药物中的应用；尤其涉及式（I）所示的衍生物化合物、其同系物或其药学上可接受的组合物。
• OPIOID RECEPTOR LIGANDS AND METHODS OF USING AND MAKING SAME
  申请人：Trevena, Inc.

  公开号：EP2688403B1

  公开（公告）日：2017-05-31