methyl 4-({[(tert-butoxy)carbonylamino]amino}methyl)benzoate | 349105-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-({[(tert-butoxy)carbonylamino]amino}methyl)benzoate
• 英文别名: tert-butyl 2-[4-(methoxycarbonyl)benzyl]hydrazinecarboxylate；methyl 4-[[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]methyl]benzoate
• CAS: 349105-56-2
• 化学式: C₁₄H₂₀N₂O₄
• 分子量: 280.324
• InChiKey: GBIGWQAJLXBOSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 4-({[(tert-butoxy)carbonylamino]amino}methyl)benzoate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 生成 [4-(methoxycarbonyl)benzyl]hydrazinium chloride
  参考文献：
  名称：

  WO2006/17055

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl (2E)-2-[4-(methoxycarbonyl)benzylidene]hydrazinecarboxylate 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 48.0h， 生成 methyl 4-({[(tert-butoxy)carbonylamino]amino}methyl)benzoate
  参考文献：
  名称：

  WO2006/17055

  摘要：

  公开号：

文献信息

• Methods and compositions for the treatment of pain
  申请人：——

  公开号：US20030181449A1

  公开（公告）日：2003-09-25

  A method for the treatment of pain is disclosed comprising administration of a pain-ameliorating effective amount of any compound according to structural diagram I; 1 wherein A, D and R 1 are as defined in the specification. Also disclosed are pharmaceutical compositions comprising a pain-ameliorating effective amount of a compound in accord with structural diagram I.

  本发明揭示了一种治疗疼痛的方法，包括给予结构图I中的任何化合物的疼痛减轻有效量，其中A、D和R1如规范所定义。此外，本发明还揭示了包括符合结构图I的化合物的疼痛减轻有效量的药物组合物。
• Pyrazole Amide Derivatives, Compositions Containing Such Compounds And Methods Of Use
  申请人：Beeson Teresa

  公开号：US20070203186A1

  公开（公告）日：2007-08-30

  Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  本文介绍了吡唑酰胺类化合物，其适用于治疗2型糖尿病及相关疾病。同时还包括药物组合物和治疗方法。
• Pyrazole amide derivatives, compositions containing such compounds and methods of use
  申请人：Merck & Co., Inc.

  公开号：US07649009B2

  公开（公告）日：2010-01-19

  Pyrazole amides are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

  本文揭示了吡唑酰胺类化合物，该化合物可用于治疗2型糖尿病及相关疾病。同时还包括制药组合物和治疗方法。
• Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain
  作者：Thomas M. Bare、Dean G. Brown、Carey L. Horchler、Megan Murphy、Rebecca A. Urbanek、Vernon Alford、Christine Barlaam、Martin C. Dyroff、James B. Empfield、Janet M. Forst、Keith J. Herzog、Richard A. Keith、Alan S. Kirschner、Chi-Ming C. Lee、Joseph Lewis、Frances M. McLaren、Kathy L. Neilson、Gary B. Steelman、Shephali Trivedi、Edward P. Vacek、Wenhua Xiao

  DOI：10.1021/jm060212s

  日期：2007.6.1

  A series of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones were synthesized and found to have potent activity at the glycine site of the NMDA receptor. In some cases, these compounds possessed poor aqueous solubility that may have contributed to poor rat oral bioavailability. Subsequently, compounds have been identified with improved aqueous solubility and oral bioavailability. Several of these compounds were examined in a rat chronic constrictive injury (CCI) model of neuropathic pain and found to have potent activity when dosed orally.
• METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN
  申请人：AstraZeneca AB

  公开号：EP1244660A1

  公开（公告）日：2002-10-02