5,5,5-trifluoro-2-morpholin-2-yl-1-{2-[trifluoromethyloxy]phenyl}pentan-2-ol hydrochloride | 852236-95-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5,5,5-trifluoro-2-morpholin-2-yl-1-{2-[trifluoromethyloxy]phenyl}pentan-2-ol hydrochloride
• 英文别名: 5,5,5-Trifluoro-2-morpholin-2-yl-1-[2-(trifluoromethoxy)phenyl]pentan-2-ol;hydrochloride
• CAS: 852236-95-4
• 化学式: C₁₆H₁₉F₆NO₃*ClH
• 分子量: 423.783
• InChiKey: QJNNUNXWAJGWLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  50.7
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• Morpholine derivatives as norepinephrine reuptake inhibitors
  申请人：Eli Lilly and Company

  公开号：EP2223916A1

  公开（公告）日：2010-09-01

  Compounds of the general formula (I) are inhibitors of the reuptake of norepinephrine. As such, they may be useful for the treatment of disorders of the central and/or peripheral nervous system.

  通式（I）化合物是去甲肾上腺素再摄取抑制剂。 因此，它们可用于治疗中枢和/或周围神经系统疾病。
• MORPHOLINE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1682523B1

  公开（公告）日：2010-08-18
• 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR
  申请人：Amira Pharmaceuticals, Inc.

  公开号：EP2212312A2

  公开（公告）日：2010-08-04
• US7423037B2
  申请人：——

  公开号：US7423037B2

  公开（公告）日：2008-09-09
• [EN] 5-LIPOXYGENASE ACTIVATING PROTEIN (FLAP) INHIBITOR<br/>[FR] INHIBITEUR DE LA PROTÉINE D'ACTIVATION DE LA 5-LIPOXYGÉNASE (FLAP)
  申请人：AMIRA PHARMACEUTICALS INC

  公开号：WO2009055721A2

  公开（公告）日：2009-04-30

  Described herein are methods for the synthesis of 3-[5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyridin-5-yl)benzyl]-indol-2-yl]-2,2-dimethyl-propionic acid, pharmaceutically acceptable salts, pharmaceutically acceptable solvates thereof. Also described are pharmaceutical compositions suitable for oral administration to a mammal, as well as methods of using such oral pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.