propan-2-yl 3-oxopiperazine-1-carboxylate | 1341479-55-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propan-2-yl 3-oxopiperazine-1-carboxylate
• CAS: 1341479-55-7
• 化学式: C₈H₁₄N₂O₃
• 分子量: 186.211
• InChiKey: NGVURWHMMTVPQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 3-SUBSTITUTED-6-(PYRIDINYLMETHOXY)-PYRROLOPYRIDINE COMPOUNDS
  申请人：Lamas-Peteira Carlos

  公开号：US20130225602A1

  公开（公告）日：2013-08-29

  The invention provides certain 3-substituted-6-(pyridinylmethoxy)-pyrrolopyridine compounds, particularly compounds of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat Parkinsons disease Formula (I).

  本发明提供了某些3-取代-6-(吡啶基甲氧基)-吡咯吡啶化合物，特别是化合物I及其制药组合物。本发明还提供了使用化合物I治疗帕金森病的方法。化合物I的结构式如下：
• BICYCLOAMINE DERIVATIVE
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2241567A1

  公开（公告）日：2010-10-20

  Compounds represented by formula (I) and pharmaceutically acceptable salts thereof have excellent sodium channel inhibitory action and are useful as therapeutic agents and analgesics for various kinds of neuralgia, neuropathy, epilepsy, insomnia, premature ejaculation and the like. wherein Q represents ethylene, etc., R1, R2 and R3 represent hydrogen, etc., X1 represents C1-6 alkylene, etc., X2 represents C1-6 alkylene, etc., A1 represents a 5- to 6-membered heterocyclic group, etc., and A2 represents C6-14 aryl, etc.

  式 (I) 所代表的化合物及其药学上可接受的盐类具有出色的钠通道抑制作用，可用作各种神经痛、神经病、癫痫、失眠、早泄等疾病的治疗剂和镇痛剂。 其中 Q 代表乙烯等，R1、R2 和 R3 代表氢等，X1 代表 C1-6 亚烷基等，X2 代表 C1-6 亚烷基等，A1 代表 5 至 6 元杂环基团等，A2 代表 C6-14 芳基等。
• COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：Bronk Brian Scott

  公开号：US20110251379A1

  公开（公告）日：2011-10-13

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• Compounds useful for treating neurodegenerative disorders
  申请人：Bronk Brian Scott

  公开号：US20130060013A1

  公开（公告）日：2013-03-07

  The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein each of the variables listed above are as defined and described herein, compositions thereof, and methods of using the same.
• US8778946B2
  申请人：——

  公开号：US8778946B2

  公开（公告）日：2014-07-15