2-(Boc-amino) ethyl-L-alanine methyl ester | 149376-72-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(Boc-amino) ethyl-L-alanine methyl ester
• 英文别名: N-(N-Boc-aminoethyl)L-alanine methyl ester；2-(BOC-amino)ethyl-L-alanine methyl ester；methyl (2S)-2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]propanoate
• CAS: 149376-72-7
• 化学式: C₁₁H₂₂N₂O₄
• 分子量: 246.307
• InChiKey: KMLNANWCWJBPDL-QMMMGPOBSA-N

物化性质

• 沸点：
  346.3±27.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-叔丁氧羰基-2-氨基乙醛 、 L-丙氨酸甲酯盐酸盐 在 钯 sodium acetate 作用下， 以 甲醇 、 水 为溶剂， 以6.36 g (94%)的产率得到2-(Boc-amino) ethyl-L-alanine methyl ester
  参考文献：
  名称：

  Synthetic procedures for peptide nucleic acids

  摘要：

  一种新型化合物类别，被称为肽核酸，比相应的DNA更强烈地结合互补的单链DNA和RNA链。肽核酸通常包括配体，如天然存在的DNA碱基，通过适当的连接剂连接到肽骨架上。

  公开号：

  US06713602B1

文献信息

• Peptide nucleic acids having 2,6-diaminopurine nucleobases
  申请人：——

  公开号：US06414112B1

  公开（公告）日：2002-07-02

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. The peptide nucleic acids of the invention comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone. Some PNAs of the invention also contain C1-C8 alkylamine side chains.

  一种新型化合物类别，被称为肽核酸，比相应的DNA链和RNA链结合更牢固，并表现出增强的序列特异性和结合亲和力。该发明的肽核酸包括从天然存在的核碱基和连接到聚酰胺骨架的非天然核碱基中选择的配体。该发明的一些肽核酸还包含C1-C8烷基胺侧链。
• Peptide nucleic acids
  申请人：——

  公开号：US05539082A1

  公开（公告）日：1996-07-23

  A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

  一种新型化合物，被称为肽核酸，比相应的DNA更强烈地结合互补的单链DNA和RNA链。肽核酸通常包括配体，例如天然存在的DNA碱基，通过适当的连接剂连接到肽骨架上。
• Peptide nucleic acids having enhanced binding affinity, sequence
  申请人：——

  公开号：US05714331A1

  公开（公告）日：1998-02-03

  A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.

  一种新型化合物，被称为肽核酸，比相应的DNA链和RNA链结合更牢固，并表现出增强的序列特异性和溶解性。肽核酸包括从天然存在的核碱基和连接到聚酰胺骨架的非天然存在的核碱基中选择的配体，并含有C.sub.1 -C.sub.8烷基胺侧链。提供了增强PNAs溶解性、结合亲和力和序列特异性的方法。
• Double-stranded peptide nucleic acids
  申请人：——

  公开号：US06228982B1

  公开（公告）日：2001-05-08

  A novel class of compounds, known as peptide nucleic acids, form double-stranded structures with one another and with ssDNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.

  一种新型化合物，被称为肽核酸，彼此之间和与单链DNA形成双链结构。肽核酸通常包括配体，例如天然存在的DNA碱基，通过适当的连接剂连接到肽骨架上。
• Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
  申请人：——

  公开号：US06710164B1

  公开（公告）日：2004-03-23

  A novel class of compounds known as peptide nucleic acids, bind complementary DNA and RNA strands, and generally do so more strongly than the corresponding DNA or RNA strands while exhibiting increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases, including 2,6-diaminopurine, attached to a polyamide backbone, and contain alkyl amine side chains.

  一种被称为肽核酸的新型化合物类别，能够结合互补的DNA和RNA链，通常比相应的DNA或RNA链结合更牢固，同时表现出增强的序列特异性和溶解性。肽核酸包括从天然存在的核碱基和非天然存在的核碱基（包括2,6-二氨基嘌呤）中选择的配体，这些配体连接在聚酰胺骨架上，并含有烷基胺侧链。