(S)-2-(2-BENZOYLPHENYLAMINO)-3-{3`-[3-(4-DIMETHYLAMINOPHENYL)-1-METHYLUREIDO] biphenyl-4-YL} propionic acid | 692257-88-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-(2-BENZOYLPHENYLAMINO)-3-{3`-[3-(4-DIMETHYLAMINOPHENYL)-1-METHYLUREIDO] biphenyl-4-YL} propionic acid
• 英文别名: (S)-3-{3'-[3(4-dimethylaminophenyl)-1-methylureido]biphenyl-4-yl}-2-[2-(1-phenylmethanoyl)-phenylamino]propionic acid；(S)-2-(2-benzoylphenylamino)-3-{3'-[3-(4-dimethylaminophenyl)-1-methylureido]biphenyl-4-yl}propionic acid；(2S)-2-(2-benzoylanilino)-3-[4-[3-[[4-(dimethylamino)phenyl]carbamoyl-methylamino]phenyl]phenyl]propanoic acid
• CAS: 692257-88-8
• 化学式: C₃₈H₃₆N₄O₄
• 分子量: 612.728
• InChiKey: LMZHWXAKHLYFBX-DHUJRADRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  102
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (S)-3-[3'-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-[2-(1-phenylmethanoyl)phenylamino]propionic acid 、 ethyl (S)-2-(2-BENZOYLPHENYLAMINO)-3-{3`-[3-(4-DIMETHYLAMINOPHENYL)-L-METHYLUREIDO] BIPHENYL-4-yl} propionate 、 氢氧化锂 以0.41 g of (S)-2-(2-benzoylphenylamino)-3-{3′-[3-(4-dimethylaminophenyl)-1-methylureido]biphenyl-4-yl}propionic acid is obtained with an 89% yield的产率得到(S)-2-(2-BENZOYLPHENYLAMINO)-3-{3`-[3-(4-DIMETHYLAMINOPHENYL)-1-METHYLUREIDO] biphenyl-4-YL} propionic acid
  参考文献：
  名称：

  Biaromatic compounds which activate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof

  摘要：

  具有下面结构式（I）的新型双芳香族化合物，制成适用于人类或兽医药物的制剂（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域中），或者制成化妆品制剂。

  公开号：

  US07807669B2

文献信息

• Novel biaromatic compounds which activate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20050256116A1

  公开（公告）日：2005-11-17

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有下列结构式（I）的新型双芳香化合物被用于制备适用于人类或兽医药学（在皮肤科、心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者制备化妆品组合物。
• NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE PPARY TYPE RECEPTORS AND COSMETIC/PHARMACEUTICAL COMPOSITIONS COMPRISED THEREOF
  申请人：CLARY LAURENCE

  公开号：US20090062340A1

  公开（公告）日：2009-03-05

  Novel biaromatic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香族化合物被制成适合于在人类或兽医学中（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域中）进行治疗的制药组合物，或者制成化妆品组合物。
• PROCESS FOR THE PRODUCTION OF PURINE DERIVATIVES AND INTERMEDIATES THEREFOR
  申请人：Novartis International Pharmaceutical Ltd.

  公开号：EP1068209B1

  公开（公告）日：2005-09-14
• BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：GALDERMA RESEARCH & DEVELOPMENT

  公开号：EP1575911B1

  公开（公告）日：2010-01-13
• BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1575911A2

  公开（公告）日：2005-09-21