(R)-N-(3-(2-(2-(3-chloroindazol-6-yloxy)ethylamino)-1-hydroxyethyl)phenyl)thiophene-3-sulfonamide | 1283127-70-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (R)-N-(3-(2-(2-(3-chloroindazol-6-yloxy)ethylamino)-1-hydroxyethyl)phenyl)thiophene-3-sulfonamide
• 英文别名: N-[3-[(1R)-2-[2-[(3-chloro-2H-indazol-6-yl)oxy]ethylamino]-1-hydroxyethyl]phenyl]thiophene-3-sulfonamide
• CAS: 1283127-70-7
• 化学式: C₂₁H₂₁ClN₄O₄S₂
• 分子量: 493.007
• InChiKey: QVXCDIMAZKJMBN-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• INDAZOLE ANALOG
  申请人：Wada Yasuhiro

  公开号：US20120225909A1

  公开（公告）日：2012-09-06

  [Objective] To provide a drug that selectively stimulates the β3-adrenergic receptors, particularly a drug capable of preferentially stimulating the β3-adrenergic receptors over the α1-adrenergic receptors. This drug can be used in the treatment and prevention of diabetes, obesity, hyperlipidemia, depression, cholelithiasis, diseases caused by biliary hyperkinesia, diseases caused by hyperfunction of the gastrointestinal tract, interstitial cystitis, overactive bladder or urinary incontinence, diseases associated with decreased lacrimation, and the like. [Solution] Indazole analogs represented by the general formula (I) or a salt thereof. Drugs that contains these indazole analogs or a salt thereof as the active ingredient.

  【目的】提供一种选择性刺激β3-肾上腺素能受体的药物，特别是一种能够优先刺激β3-肾上腺素能受体而非α1-肾上腺素能受体的药物。该药可以用于糖尿病、肥胖症、高脂血症、抑郁症、胆石症、胆道高动力症引起的疾病、胃肠道高功能引起的疾病、间质性膀胱炎、过度活动的膀胱或尿失禁、伴有泪液减少的疾病等的治疗和预防。 【解决方案】一般式（I）所代表的吲唑类似物或其盐。包含这些吲唑类似物或其盐作为活性成分的药物。