4-乙氧基苯甘氨酸

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-乙氧基苯甘氨酸
• 中文别名: 4-乙氧基-DL-苯甘氨酸；氨基-(4-乙氧基-苯基)-乙酸
• 英文名称: 2-azaniumyl-2-(4-ethoxyphenyl)acetate
• 化学式: C10H13NO3
• mdl: MFCD00665360
• 分子量: 195.21
• InChiKey: YUWLNORTZKHHKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Boron-containing diacylhydrazine compounds
  申请人：Intrexon Corporation

  公开号：US10570158B2

  公开（公告）日：2020-02-25

  The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R4, and R5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.

  本公开提供了具有式 I 的含硼二酰肼： 及其药学上可接受的盐和溶液，其中 A、R4 和 R5 的定义如说明书所述。本公开还提供了含硼二酰肼在基于蜕皮激素受体的诱导基因表达系统中的应用。因此，本公开可用于基因治疗、疾病治疗、蛋白质和抗体的大规模生产、基于细胞的筛选测定、功能基因组学、蛋白质组学、代谢组学以及转基因生物的性状调控等需要控制基因表达水平的应用领域。
• Boron-Containing Diacylhydrazine Compounds
  申请人：Intrexon Corporation

  公开号：US20180201628A1

  公开（公告）日：2018-07-19

  The present disclosure provides boron-containing diacylhydrazines having Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein A, R 4 , and R 5 are defined as set forth in the specification. The present disclosure also provides the use of boron-containing diacylhydrazines is ecdysone receptor-based inducible gene expression systems. Thus, the present disclosure is useful for applications such as gene therapy, treatment of disease, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable.