cis-2-(2-chloroacetoxy)cyclohexyl isobutyrate | 1228440-16-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-2-(2-chloroacetoxy)cyclohexyl isobutyrate
• CAS: 1228440-16-1
• 化学式: C₁₂H₁₉ClO₄
• 分子量: 262.733
• InChiKey: JEJLLGQYBWJQCL-ZJUUUORDSA-N

反应信息

• 作为产物：
  描述：

  异丁酸酐 、 cis-1,2-cyclohexanediol monochloroacetate 在 methyl (S)-2-(3,5-di-tert-butylphenylthioamido)-3-(1-methyl-1H-imidazol-5-yl)propanoate 、 N,N-二异丙基乙胺 作用下， 以 四氯化碳 为溶剂， 反应 3.0h， 生成 cis-2-(2-chloroacetoxy)cyclohexyl isobutyrate 、 cis-2-(2-chloroacetoxy)cyclohexyl isobutyrate
  参考文献：
  名称：

  Desymmetrization of meso-1,2-Diols via the Dynamic Kinetic Resolution of Its Monodichloroacetates

  摘要：

  Enantioselective acylation catalyzed by the thioamide modified 1-methylhistidine methyl ester 1 in combination with DABCO-mediated racemization of the substrate led to the efficient dynamic kinetic resolution or meso-1,2-diol monodichloroacetates. In this way, cyclic and acyclic meso-1,2-diol monodichloroacetates can be transformed to the enantiomerically enriched (1S,2R)-heterosubstituted diol diesters which are stable in enantiomerically pure form and can be readily used for further organic transformations.

  DOI：

  10.1021/jo100435f