(E)-N,N-dimethyl-3-(3-methyl-5-phenyl-1,2-oxazol-4-yl)prop-2-enamide | 1312294-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N,N-dimethyl-3-(3-methyl-5-phenyl-1,2-oxazol-4-yl)prop-2-enamide
• CAS: 1312294-15-7
• 化学式: C₁₅H₁₆N₂O₂
• 分子量: 256.304
• InChiKey: ZVXQVNTXPNZCNF-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-甲基-5-苯基噁唑 、 N,N-二甲基丙烯酰胺 在 copper diacetate 、 palladium diacetate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 8.0h， 以58%的产率得到(E)-N,N-dimethyl-3-(3-methyl-5-phenyl-1,2-oxazol-4-yl)prop-2-enamide
  参考文献：
  名称：

  Studies on the palladium-catalysed direct alkenylation of 1,2-azoles

  摘要：

  Electron-rich isoxazoles, isothiazoles and pyrazoles undergo palladium-catalysed direct alkenylation in moderate yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.051

文献信息

• Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
  申请人：——

  公开号：US20030149051A1

  公开（公告）日：2003-08-07

  The present invention provides compounds of formula I: 1 where R 1 is H, CONH 2 , T (n) —R, or T (n) —Ar 2 , n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明提供了公式I的化合物：其中R1为H、CONH2、T(n)—R或T(n)—Ar2，n可以是零或一，而G、XYZ和Q如下所述。这些化合物是蛋白激酶的抑制剂，特别是JNK的抑制剂，JNK是一种参与细胞增殖、细胞死亡和对细胞外刺激反应的哺乳动物蛋白激酶。该发明还涉及生产这些抑制剂的方法。该发明还提供包含该发明中的抑制剂的药物组合物，并提供利用这些组合物在治疗和预防各种疾病中的方法。
• Inhibitors of c-jun N terminal kinases (JNK) and other protein kinases
  申请人：Green Jeremy

  公开号：US20050026967A1

  公开（公告）日：2005-02-03

  The present invention provides compounds of formula I: where R 1 is H, CONH 2 , T( n )—R, or T( n )—Ar 2 , n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明提供式I的化合物：其中R1为H、CONH2、T（n）—R或T（n）—Ar2，n可以为零或一，而G、XYZ和Q如下所述。这些化合物是蛋白激酶抑制剂，特别是JNK的抑制剂，JNK是哺乳动物蛋白激酶，涉及细胞增殖、细胞死亡和对细胞外刺激的反应。本发明还涉及制备这些抑制剂的方法。本发明还提供了包含本发明抑制剂的制药组合物和利用这些组合物在治疗和预防各种疾病的方法。
• INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES
  申请人：VERTEX PHARMACEUTICALS INCORPORATED

  公开号：EP1218369B1

  公开（公告）日：2008-07-23
• US6693108B2
  申请人：——

  公开号：US6693108B2

  公开（公告）日：2004-02-17
• US7169798B2
  申请人：——

  公开号：US7169798B2

  公开（公告）日：2007-01-30