N-tert-butyl-3-hydroxy-2,2-dimethylpropanamide | 1522363-45-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-tert-butyl-3-hydroxy-2,2-dimethylpropanamide
• CAS: 1522363-45-6
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: OCJPXEITUXHWMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-butylpivalamide 在 甲醇 、 dipotassium peroxodisulfate 、 palladium diacetate 、 potassium carbonate 作用下， 反应 20.0h， 生成 N-tert-butyl-3-hydroxy-2,2-dimethylpropanamide
  参考文献：
  名称：

  Palladium-Catalyzed β-Acyloxylation of Simple Amide via sp³ C–H Activation

  摘要：

  beta-Acylcoxy amides are prepared in moderate to high yields by palladium-catalyzed acyloxylation of primary sp(3) C-H bonds from simple amides without any special directing group. A catalytic system of Pd(OAc)(2)/CF3CO2H/K2S2O8 is available to various amides with N-substituted by linear alkanes, cyclic alkanes, and electron-deficient benzyl compounds in this reaction. Acyloxylated products could be transformed easily to the corresponding beta-hydroxy amides.

  DOI：

  10.1021/ol403393w

文献信息

• PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
  申请人：Senomyx, Inc.

  公开号：US20170327479A1

  公开（公告）日：2017-11-16

  The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.