(S)-5-bromo-N2-(1-(3,5-difluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | 915720-34-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-5-bromo-N2-(1-(3,5-difluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
• 英文别名: 5-bromo-2-N-[(1S)-1-(3,5-difluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
• CAS: 915720-34-2
• 化学式: C₁₇H₁₈BrF₂N₇O
• 分子量: 454.277
• InChiKey: UVKMZLMUXKAPEI-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Pyrazolylaminopyrimidine Derivatives Useful as Tyrosine Kinase Inhibitors
  申请人：Wang Bin

  公开号：US20080287437A1

  公开（公告）日：2008-11-20

  This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.

  本发明涉及具有以下公式（I）的新化合物，以及它们的药物组合物和使用方法。这些新化合物提供了治疗癌症的方法。
• PYRAZOLYLAMINOPYRIMIDINE DERIVATIVES USEFUL AS TYROSINE KINASE INHIBITORS
  申请人：Wang Bin

  公开号：US20100210648A1

  公开（公告）日：2010-08-19

  This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.

  这项发明涉及具有以下公式（I）的新化合物，以及它们的药物组合物和使用方法。这些新化合物可提供一种治疗癌症的方法。
• Use 540
  申请人：Claesson Alf

  公开号：US20080108633A1

  公开（公告）日：2008-05-08

  This invention relates to new use of pyrazolyl derivatives and pharmaceutically acceptable salts thereof, which have been found to possess analgesic activity and are accordingly useful in the treatment or prophylaxis of pain conditions in the human or animal body, for example in the manufacture of medicaments for the treatment or prevention of pain in a warm-blooded animal such as man.