2-(苯甲酰基氨基)-1-(3-苯丙基)-1H-苯并咪唑-5-羧酸甲酯 | 1374601-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 2-(苯甲酰基氨基)-1-(3-苯丙基)-1H-苯并咪唑-5-羧酸甲酯
• 中文别名: 化合物BRD4770；BRD4770抑制剂；EHMT2抑制剂(BRD4770)；BRD4770
• 英文名称: Brd4770
• 英文别名: methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate
• CAS: 1374601-40-7
• 化学式: C₂₅H₂₃N₃O₃
• 分子量: 413.5
• InChiKey: UCGWYCMPZXDHNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  73.2
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xn
• 危险类别码：
  R22
• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR (TALE) - LYSINE-SPECIFIC DEMETHYLASE 1 (LSD1) FUSION PROTEINS
  申请人：The General Hospital Corporation

  公开号：EP2906602B1

  公开（公告）日：2019-01-16
• COMPOSITIONS FOR PREPARING CARDIOMYOCYTES
  申请人：The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone

  公开号：EP3043822A1

  公开（公告）日：2016-07-20
• EPIGENETIC REGULATORS OF FRATAXIN
  申请人：RANA THERAPEUTICS, INC.

  公开号：US20160201063A1

  公开（公告）日：2016-07-14

  Provided herein are methods for increasing Frataxin (FXN) expression that involve targeting or expressing regulatory factors that modulate the epigenetic state of FXN genes. Also provided herein are methods for increasing FXN expression using inhibitors of a negative epigenetic regulator of FXN. Compositions and methods for treating Friedrich's ataxia are also provided.
• SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE CARDIOMYOCYTES
  申请人：The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Glad

  公开号：US20160186141A1

  公开（公告）日：2016-06-30

  Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become cardiac progenitor cells or cardiomyocytes.
• US9982231B2
  申请人：——

  公开号：US9982231B2

  公开（公告）日：2018-05-29