7-methyl-3-{4-[(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl)oxy]butoxy}-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine | 1229512-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 7-methyl-3-{4-[(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl)oxy]butoxy}-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine
• CAS: 1229512-79-1
• 化学式: C₄₀H₄₈N₂O₂
• 分子量: 588.833
• InChiKey: GLXRBNMCRYAQBV-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  7-methyl-3-{4-[(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl)oxy]butoxy}-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 7-methyl-3-{4-[(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl)oxy]butoxy}-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine dihydrochloride
  参考文献：
  名称：

  Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: Novel heterocyclic templates for butyrylcholinesterase inhibitors

  摘要：

  Three different types of homobivalent compounds, 5,8,9,13b-tetrahydro-6H-isoqino[1,2-a]isoquinolines bearing tertiary N-atoms, their quaternary ammonium salts and their dibenzazecine analogues, connected by alkylene spacers of various lengths were synthesized. Compared to the therapeutically used inhibitor galanthamine, some of the bivalent compounds showed much higher inhibitory activities at both cholinesterases in the Ellman test. Surprisingly, not only the quaternary salts, but also the uncharged tertiary compounds exhibited IC50 values at butyrylcholinesterase in the nanomolar range. Selectivity toward BChE of up to 76-fold was observed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.011
• 作为产物：
  描述：

  7-methyl-3-{4-[(7-methyl-5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolinium-3-yl)oxy]butoxy}-5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolinium diiodide 在 氨 、 sodium 作用下， 生成 7-methyl-3-{4-[(7-methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecin-3-yl)oxy]butoxy}-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine
  参考文献：
  名称：

  Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: Novel heterocyclic templates for butyrylcholinesterase inhibitors

  摘要：

  Three different types of homobivalent compounds, 5,8,9,13b-tetrahydro-6H-isoqino[1,2-a]isoquinolines bearing tertiary N-atoms, their quaternary ammonium salts and their dibenzazecine analogues, connected by alkylene spacers of various lengths were synthesized. Compared to the therapeutically used inhibitor galanthamine, some of the bivalent compounds showed much higher inhibitory activities at both cholinesterases in the Ellman test. Surprisingly, not only the quaternary salts, but also the uncharged tertiary compounds exhibited IC50 values at butyrylcholinesterase in the nanomolar range. Selectivity toward BChE of up to 76-fold was observed. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.011