(2R,3R,4S,5S,6R)-2-(5-chloro-4-(4-(cyclopentyloxy)benzyl)thiophen-2-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | 1344027-91-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2R,3R,4S,5S,6R)-2-(5-chloro-4-(4-(cyclopentyloxy)benzyl)thiophen-2-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
• 英文别名: (2R,3R,4S,5S,6R)-2-[5-chloro-4-[(4-cyclopentyloxyphenyl)methyl]thiophen-2-yl]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1344027-91-3
• 化学式: C₂₂H₂₇ClO₆S
• 分子量: 454.972
• InChiKey: AJSOYBDIYHFPDU-RQXATKFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  128
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• NOVEL THIOPHENE DERIVATIVE AS SGLT2 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Lee Jinhwa

  公开号：US20130172278A1

  公开（公告）日：2013-07-04

  The present invention relates to a novel compound with thiophene ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The prevention also provides a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating metabolic disorders, particularly diabetes.

  本发明涉及一种具有噻吩环的新化合物，具有对存在于肠和肾中的钠依赖性葡萄糖共转运体2（SGLT2）的抑制活性，并且包含该化合物作为活性成分的药物组合物，该组合物有助于预防或治疗代谢性疾病，特别是糖尿病。预防还提供了制备该化合物的方法，含有该化合物的药物组合物以及预防或治疗代谢性疾病，特别是糖尿病的方法。
• US9006187B2
  申请人：——

  公开号：US9006187B2

  公开（公告）日：2015-04-14
• [EN] NOVEL THIOPHENE DERIVATIVE AS SGLT2 INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] NOUVEAU DÉRIVÉ DU THIOPHÈNE UTILISÉ COMME INHIBITEUR DU SGLT2 ET COMPOSITION PHARMACEUTIQUE COMPRENANT CE DÉRIVÉ
  申请人：GREEN CROSS CORP

  公开号：WO2012033390A2

  公开（公告）日：2012-03-15

  The present invention relates to a novel compound with thiophene ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes. The prevention also provides a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating metabolic disorders, particularly diabetes.