(S)-2-Amino-2-cyclohexyl-1-pyrrolidin-1-yl-ethanone | 171092-49-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-Amino-2-cyclohexyl-1-pyrrolidin-1-yl-ethanone
• 英文别名: (2S)-2-amino-2-cyclohexyl-1-(pyrrolidin-1-yl)ethan-1-one；(2S)-2-amino-2-cyclohexyl-1-pyrrolidin-1-ylethanone
• CAS: 171092-49-2
• 化学式: C₁₂H₂₂N₂O
• 分子量: 210.319
• InChiKey: RWNSISJNBAQNTF-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ((S)-1-Cyclohexyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-carbamic acid tert-butyl ester 在 acid 作用下， 生成 (S)-2-Amino-2-cyclohexyl-1-pyrrolidin-1-yl-ethanone
  参考文献：
  名称：

  New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors

  摘要：

  Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.026

文献信息

• SMAC MIMETICS USED AS IAP INHIBITORS AND USE THEREOF
  申请人：Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

  公开号：EP3712162A1

  公开（公告）日：2020-09-23

  Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particular breast cancer.

  公开了一类用作 IAP 抑制剂的 SMAC 拟态化合物，特别是公开了如式 (I) 所示的化合物、其异构体及其药学上可接受的盐类。IAP 抑制剂是治疗癌症，特别是乳腺癌的药物。
• COMBINATION OF IAP INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：EP3936126A1

  公开（公告）日：2022-01-12

  The present invention relates to a combination of a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof which are used as an IAP inhibitor, and an immune checkpoint inhibitor; and use of the combination in the preparation of a cancer treatment drug.

  本发明涉及一种由式（I）代表的化合物、其异构体或其药学上可接受的盐组成的组合物，可用作 IAP 抑制剂和免疫检查点抑制剂；以及该组合物在制备癌症治疗药物中的用途。
• ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES
  申请人：Nuevolution A/S

  公开号：EP3018206B1

  公开（公告）日：2021-08-11
• [EN] METHODS AND COMPOSITIONS RELATING TO IMMUNOSTIMULATION<br/>[FR] MÉTHODES ET COMPOSITIONS CONCERNANT UNE IMMUNOSTIMULATION
  申请人：POINT THERAPEUTICS INC

  公开号：WO2007127204A2

  公开（公告）日：2007-11-08

  [EN] The invention relates to methods for immunostimulation involving inhibition of DPP8 and/or 9.
  [FR] L'invention concerne des méthodes d'immunostimulation qui impliquent une inhibition de DPP8 et/ou 9.