6-O-Propionyl-ascorbinsaeure | 13114-55-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-O-Propionyl-ascorbinsaeure
• 英文别名: 3,4-dihydroxy-5-(1-hydroxy-2-propionyloxy-ethyl)-5H-furan-2-one；[2-(3,4-dihydroxy-5-oxo-2H-furan-2-yl)-2-hydroxyethyl] propanoate
• CAS: 13114-55-1
• 化学式: C₉H₁₂O₇
• 分子量: 232.19
• InChiKey: QKQGHRKMOHKMHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• BRAIN-TARGETING PRODRUG FOR AMPA RECEPTOR SYNERGIST, AND PHARMACEUTICAL APPLICATIONS
  申请人：Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

  公开号：EP3444240A1

  公开（公告）日：2019-02-20

  Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.

  本发明公开了式(I)化合物、几何或光学异构体、药学上可接受的盐、其溶解物或多晶型物。本发明还公开了一种包含式（I）化合物、几何或光学异构体、药学上可接受的盐、其溶液或其多晶型的组合物。本发明还公开了式(I)化合物、几何异构体或光学异构体、药学上可接受的盐、其溶解物或其多晶型在治疗疾病或紊乱中的用途，例如低谷氨酸症、神经退行性疾病或呼吸抑制，特别是在治疗与AMPA受体相关的疾病或紊乱中的用途。