4-乙酰氧基-4'-(三氟甲基)联苯 | 126485-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-乙酰氧基-4'-(三氟甲基)联苯
• 英文名称: 4-acetoxy-4'-(trifluoromethyl)biphenyl
• 英文别名: [4-[4-(Trifluoromethyl)phenyl]phenyl] acetate
• CAS: 126485-56-1
• 化学式: C₁₅H₁₁F₃O₂
• 分子量: 280.246
• InChiKey: CZXYMAROEFKHBK-UHFFFAOYSA-N

物化性质

• 沸点：
  330.0±42.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Dichloro(propyl)<(4-trifluoromethyl)phenyl>silane 在 bis(η3-allyl-μ-chloropalladium(II)) potassium fluoride 、 三氟化锑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 4-乙酰氧基-4'-(三氟甲基)联苯
  参考文献：
  名称：

  Hatanaka, Yasuo; Fukushima, Satoshi; Hiyama, Tamejiro, Chemistry Letters, 1989, p. 1711 - 1714

  摘要：

  DOI：

文献信息

• Aryl and heteroaryl compounds, compositions, and methods of use
  申请人：Mjalli M.M. Adnan

  公开号：US20050059713A1

  公开（公告）日：2005-03-17

  This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.

  本发明提供了公式(I)所描述的芳基和杂环芳基化合物，以及它们的制备方法。还提供了由公式(I)化合物制成的制药组合物和制备这种组合物的方法。公式(I)化合物可能有助于治疗包括正痘病毒在内的病毒感染，可以单独使用或与其他治疗剂联合使用。
• Highly selective cross-coupling reactions of aryl(halo)silanes with aryl halides: A general and practical route to functionalized biaryls
  作者：Yasuo Hatanaka、Ken-ichi Goda、Yoshinori Okahara、Tamejiro Hiyama

  DOI：10.1016/s0040-4020(01)85554-x

  日期：1994.1

  The palladium catalyzed cross-coupling reaction of aryl halides with aryl(halo)silanes (halogen= F, Cl) gives good yields of unsymmetrical biaryls and p-terphenyls. The reaction takes place smoothly in N,N-dimethylformamide in the presence of an appropriate palladium catalyst and potassium fluoride. Since this reaction is tolerant of a variety of reactive functional groups, highly functionalized 4,4'-, 3,4'-, 2,4'- and even sterically crowded 2,2'-disubstituted biaryls can be obtained in moderate to high yields. The synthetic utility of the method has been demonstrated by its application to a short synthesis of liquid crystals. Mechanistic aspects of transmetalation of an aryl(fluoro)silicate intermediate with a palladium complex are discussed on the basis of the substituent effects on the rate of the cross-coupling reactions.
• HATANAKA, YASUO;FUKUSHIMA, STASOHI;HIYAMA, TAMEJIRO, CHEM. LETT.,(1989) N0, C. 1711-1714
  作者：HATANAKA, YASUO、FUKUSHIMA, STASOHI、HIYAMA, TAMEJIRO

  DOI：——

  日期：——
• Hatanaka Yasuo, Goda Ken-ichi, Okahara Yoshinori, Hiyama Tamejiro, Tetrahedron, 50 (1994) N 28, S 8301-8316
  作者：Hatanaka Yasuo, Goda Ken-ichi, Okahara Yoshinori, Hiyama Tamejiro

  DOI：——

  日期：——
• US7459472B2
  申请人：——

  公开号：US7459472B2

  公开（公告）日：2008-12-02