3,4-dihydro-2H-pyran-2-ylmethyl 4-aminobenzoate | 16081-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-dihydro-2H-pyran-2-ylmethyl 4-aminobenzoate
• CAS: 16081-23-5
• 化学式: C₁₃H₁₅NO₃
• 分子量: 233.267
• InChiKey: NVMWASPCUDHSSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-dihydro-2H-pyran-2-ylmethyl 4-nitrobenzoate 在 铁粉 、 氯化铵 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 50.0h， 以77.7%的产率得到3,4-dihydro-2H-pyran-2-ylmethyl 4-aminobenzoate
  参考文献：
  名称：

  Self-assembled polymeric micelles based on THP and THF linkage for pH-responsive drug delivery

  摘要：

  Developing smart nanocarriers for drug delivery system is advantageous for many kinds of successful biomedicinal therapy. In this study, we designed an amphiphilic block copolymers containing pH-responsive tetrahydropyran (THP) and tetrahydrofuran (THF) linkage. Their structures were confirmed by H-1 NMR and gel permeation chromatography (GPC). The release rate of encapsulated drugs depends upon the pH value and pH sensitive linkage in the backbone of copolymers. For PLA THP PEG micelles the cumulative relea,se amount of doxorubicin (DOX) was 62% at pH 5.0, which is about four times higher than that at pH 7.4. Under the same conditions the release rate for PLA THF PEG micelles is a little faster than that of the PLA THP PEG micelles. Cellular uptake study demonstrates that DOX-loaded micelles can easily enter the cells and produce the desired pharmacological action and minimizing the side effect of free DOX. These findings indicate that THP and THF linked diblock copolymer micelles is a promising candidate for drug carrier. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2014.05.010