11-(N-tert-Butyl-amino)-undecansaeure | 92866-78-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 11-(N-tert-Butyl-amino)-undecansaeure
• 英文别名: 11-(Tert-butylamino)undecanoic acid
• CAS: 92866-78-9
• 化学式: C₁₅H₃₁NO₂
• 分子量: 257.417
• InChiKey: ALYVAGGUZPNUNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• NATURAL SAPONIN-BASED SYNTHETIC IMMUNOADJUVANTS
  申请人：THE UAB RESEARCH FOUNDATION

  公开号：US20150050319A1

  公开（公告）日：2015-02-19

  The present disclosure encompasses QS-21-based structurally-defined adjuvants to address the need for stronger, safer, and easier-to-access adjuvants. The new compositions can provide tools for addressing long-standing mechanistic questions concerning saponin immune-potentiation through structure-activity-relationship (SAR) studies. Most advantageously, the compounds of the disclosure may be formulated into pharmaceutically acceptable compositions, including vaccines that may be delivered to a subject human or animal subject. The compounds can then act as, for example, an adjuvant to augment an immunological response to a vaccine immunogen.
• SAPONIN-BASED VACCINE ADJUVANTS
  申请人：THE UAB RESEARCH FOUNDATION

  公开号：US20220152196A1

  公开（公告）日：2022-05-19

  A number of MS- and natural-saponin-based vaccine adjuvant candidates have been prepared. The MS derivatives were prepared by incorporating a terminal-functionalized side chain into the C3 glucuronic acid unit of the natural saponins MS I and II through amide formation reaction; and the QS analogs were prepared via multi-step organic synthesis. These unnatural saponins showed significantly different immunostimulant activity profiles, suggesting that the structure of side chain, triterpenoid core, and oligosaccharide domain together orchestrate each saponin's characteristic potentiation of immune responses.