| 1586818-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• CAS: 1586818-73-6
• 化学式: C₂₁H₁₇NO₆
• 分子量: 379.369
• InChiKey: ZLXHLDPXPASQJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  28.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  89.98
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  、 以 间二甲苯 为溶剂， 反应 10.0h， 以55%的产率得到methyl 3-hydroxy-1,7-bis(4-methoxyphenyl)-4-(4-methylbenzoyl)-9-(2-naphthalen-2-ylcarbonyl)-2,6-dioxo-1,7-diazaspiro[4.4]nona-3,8-diene-8-carboxylate
  参考文献：
  名称：

  Five-membered 2,3-dioxo heterocycles: CV. Reaction of methyl 1-aryl-3-aroyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with methyl 2-arylamino-4-(2-naphthyl)-4-oxobut-2-enoates. Crystal and molecular structure of substituted 1,7-diazaspiro[4.4]nonane

  摘要：

  DOI：

  10.1134/s1070428014070148

文献信息

• Spirobisheterocyclization of 5-(Methoxycarbonyl)-1H-pyrrol-2,3-diones by the action of enaminoesters. Crystal and molecular structure of 1,7-diazaspiro[4.4]nonane
  作者：A. Yu. Dubovtsev、E. S. Denislamova、M. V. Dmitriev、A. N. Maslivets

  DOI：10.1134/s1070428016050158

  日期：2016.5

  1-Aryl-4-aroyl-5-(methoxycarbonyl)-1Н-pyrrole-2,3-diones react with methyl 4-aryl-2-(arylamino)-4-oxobut-2-enoates with the formation of methyl 1,7-diaryl-4,9-diaroyl-3-hydroxy-2,6-dioxo-1,7-diazaspiro[4.4]nona-3,8-diene-8-carboxylates.

  1-芳基-4-芳酰基-5-（甲氧基羰基）-1--吡咯-2,3-二酮与4-芳基-2-（芳基氨基）-4-氧代丁-2-烯酸甲酯反应形成甲基1 ，7，7-二芳基-4，9-二芳基-3-羟基-2，6-二氧代-1，7-二氮杂螺[4.4]壬娜-3，8-二烯-8-羧酸盐。
• Five-membered dioxoheterocycles: XCIX. Reaction of 1-aryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with indoles. Crystal and molecular structure of substituted 2-(indol-3-yl)pyrrole
  作者：E. S. Denislamova、P. A. Slepukhin、A. N. Maslivets

  DOI：10.1134/s1070428014020146

  日期：2014.2

  1-Aryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones react with indole and 2-methylindole with the formation of methyl 1-aryl-3-aroyl-4-hydroxy-2-(1H-indol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylates. Crystal and molecular structure of methyl 3-benzoyl-4-hydroxy-2-(2-methyl-1H-indol-3-yl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-2-carboxylate was examined.
• Cycloaddition of alkenes to 4-Aroyl-1H-pyrrole-2,3-diones. crystal and molecular structure of substituted pyrano[4,3-b]pyrrole
  作者：N. V. Bubnov、E. E. Stepanova、M. V. Dmitriev、A. N. Maslivets

  DOI：10.1134/s1070428015100085

  日期：2015.10

  Methyl 3-aroyl-1-aryl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with styrene and butyl vinyl ether to give 6-substituted methyl (6R*,7aR*)-1,4-diaryl-2,3-dioxo-1,2,3,6,7,7a-hexahydropyrano-[4,3-b]pyrrole-7a-carboxylates whose structure was confirmed by X-ray analysis.